Neuronal signals regulate neurotrophin expression in oligodendrocytes of the basal forebrain

Glia
X DaiCheryl F Dreyfus

Abstract

Previous studies suggest that oligodendrocytes express trophic molecules, including neurotrophins. These molecules have been shown to influence nearby neurons. To determine whether neuronal signals may, in turn, affect oligodendrocyte-derived trophins, we examined regulation of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3) mRNA expression in cultured oligodendrocytes of the basal forebrain. Neuronal signals had distinct effects on individual neurotrophins. KCl elicited increases in BDNF mRNA, but did not affect expression of NGF or NT-3. The cholinergic agonist, carbachol, increased expression of NGF, but did not affect expression of BDNF or NT-3. Glutamate elicited a decrease in BDNF, but did not affect expression of NGF or NT-3. This glutamate effect is not due to toxicity, since the number of total cells was unchanged, while the number of mature myelin basic protein positive (MBP+) cells increased. Our observations suggest that individual neuronal signals distinctly influence the trophic function of oligodendrocytes.

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Citations

Jul 12, 2002·Journal of Neuroscience Research·Yangzhou Du, Cheryl F Dreyfus
Dec 17, 2008·Journal of Neural Transmission·Esteban Enrique AliagaL Tapia-Arancibia
Mar 11, 2008·Journal of Molecular Neuroscience : MN·Hans H AlthausMatthias Schmitz
Apr 6, 2013·Neuroscience Bulletin·Andrew N BankstonYue Feng
Feb 28, 2003·Neurotoxicology·Wenbin Deng, Ronald D Poretz
May 7, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kiren UbhiEliezer Masliah
Oct 18, 2013·Cellular and Molecular Life Sciences : CMLS·Nobukazu MiyamotoKen Arai
Mar 10, 2007·Regulatory Peptides·Frank K H van LandeghemAndreas von Deimling
Mar 20, 2004·Journal of Neurochemistry·Santina BruzzoneAntonio De Flora
Jul 23, 2008·Journal of Neurochemistry·Dana M McTigue, Richa B Tripathi
Dec 21, 2007·The European Journal of Neuroscience·Gabriela ChytrovaFernando Gomez-Pinilla
Aug 14, 2003·Brain Research·Mildred V Duprey-DíazRosa E Blanco
Sep 7, 2014·Experimental Cell Research·Kai-Hei TsePaul J Kingham
Oct 11, 2016·Molecular and Cellular Endocrinology·Dinushan Nesan, Deborah M Kurrasch
Jul 18, 2008·Multiple Sclerosis : Clinical and Laboratory Research·A Wilkins, N Scolding

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