Neuronal spike trains and stochastic point processes. II. Simultaneous spike trains

Biophysical Journal
D H PerkelG P Moore

Abstract

The statistical analysis of two simultaneously observed trains of neuronal spikes is described, using as a conceptual framework the theory of stochastic point processes.The first statistical question that arises is whether the observed trains are independent; statistical techniques for testing independence are developed around the notion that, under the null hypothesis, the times of spike occurrence in one train represent random instants in time with respect to the other. If the null hypothesis is rejected-if dependence is attributed to the trains-the problem then becomes that of characterizing the nature and source of the observed dependencies. Statistical signs of various classes of dependencies, including direct interaction and shared input, are discussed and illustrated through computer simulations of interacting neurons. The effects of nonstationarities on the statistical measures for simultaneous spike trains are also discussed. For two-train comparisons of irregularly discharging nerve cells, moderate nonstationarities are shown to have little effect on the detection of interactions.Combining repetitive stimulation and simultaneous recording of spike trains from two (or more) neurons yields additional clues as to possibl...Continue Reading

Citations

Sep 24, 1999·Hippocampus·S A Deadwyler, R E Hampson
Jan 1, 1990·Biological cybernetics·I Nelken, E Vaadia
Jan 1, 1990·Biological cybernetics·R D FrostigR M Harper
Jan 1, 1982·Biological cybernetics·C N Christakos
Mar 30, 1976·Biological cybernetics·A C Sanderson, B Kobler
Jan 1, 1988·Biological cybernetics·G PalmG L Gerstein
Jan 1, 1984·Biological cybernetics·C N Christakos
Nov 2, 1979·Biological cybernetics·W M Roberts
Jan 1, 1983·Biological cybernetics·J SchneiderH Reitböck
Jan 1, 1984·Biological cybernetics·M TsukadaG Hauske
Jan 1, 1987·Biological cybernetics·W J Melssen, W J Epping
Apr 1, 1989·Pflügers Archiv : European journal of physiology·U WindhorstJ Meyer-Lohmann
Jan 1, 1976·Neir̆ofiziologiia = Neurophysiology·B Ia Pistigorskiĭ, R V Pivnutel'
May 1, 1986·Neuroscience and Behavioral Physiology·M N Livanov
Nov 1, 1990·Neuroscience and Behavioral Physiology·I V Pavlova, V N Ponomarev
Apr 29, 1977·Documenta Ophthalmologica. Advances in Ophthalmology·B Blum
May 1, 1973·Medical & Biological Engineering·D Stagg
May 1, 1975·Medical & Biological Engineering·W WiemerH Klatt
May 1, 1975·Medical & Biological Engineering·Z J Koles, G A Kiffiak
Feb 19, 2010·Experimental Brain Research·David PutrinoSoumya Ghosh
Jan 27, 2011·Experimental Brain Research·Oscar Avila-Akerberg, Maurice J Chacron
Oct 3, 2008·Journal of Mathematical Biology·Duane Q Nykamp
Nov 6, 2012·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Roger D Longley, Misa Peterman
Sep 5, 2013·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Joshua P MartinJohn G Hildebrand
Feb 3, 2005·Biological cybernetics·Leonel GómezJosé Pedro Segundo
Mar 28, 2007·Biological cybernetics·Richard H R Hahnloser
Aug 24, 2006·Journal of Computational Neuroscience·Antonio Pazienti, Sonja Grün
Sep 26, 2006·Journal of Computational Neuroscience·Danko Nikolić

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