PMID: 9645342Jun 30, 1998Paper

Neuronal src and trk a protooncogene expression in neuroblastomas and patient prognosis

International Journal of Cancer. Journal International Du Cancer
T MatsunagaN Ohnuma

Abstract

Neuroblastomas present a wide variety of clinical and biological behaviors, which are reflected by the heterogeneous expressions of protooncogenes related to the neuronal differentiation and amplification of the N-myc gene. High expression of trk A and Ha-ras in neuroblastomas has been shown to be associated with an excellent patient outcome. We have previously reported that neuron-specific src mRNA was increased in chemically differentiated neuroblastoma cell lines and in clinically observed neuroblastomas without N-myc amplification. In the present study, to clarify both the value of neuronal c-srcN2 expression as a prognostic indicator and the significance of the coexpression of these protooncogenes, we examined the expression of 3 alternatively spliced src, trk A and Ha-ras in neuroblastoma tissues from 60 patients by competitive RNA-polymerase chain reaction (PCR). The results indicate that protooncogene expression in neuroblastomas correlated with a favorable outcome for c-srcN2 and trk A. N-myc gene was amplified exclusively in tumors with low levels of trk A. Low expression of c-srcN2 and trk A might thus characterize different aggressive phenotypes due to different signal transduction pathways of neural differentiation...Continue Reading

References

May 1, 1990·Molecular and Cellular Biology·J M Pyper, J B Bolen
Sep 15, 1994·International Journal of Cancer. Journal International Du Cancer·T MatsunagaB Simizu
Aug 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G M BrodeurF Hedborg
Mar 3, 1993·Journal of the National Cancer Institute·T SuzukiR C Seeger
Mar 25, 1993·The New England Journal of Medicine·A NakagawaraG M Brodeur
Jun 2, 1997·The EMBO Journal·W A WeissJ M Bishop
Jul 29, 1997·International Journal of Cancer. Journal International Du Cancer·P de CremouxH Magdelenat

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Citations

Mar 14, 2009·Differentiation; Research in Biological Diversity·Xiaohua XuLorene M Lanier
Aug 25, 2015·Pediatric Surgery International·Ayako TakenouchiHiroshi Shirasawa
Dec 7, 2007·Biological & Pharmaceutical Bulletin·Susumu OotsukaTakashi Suzuki
Apr 2, 2005·Biological & Pharmaceutical Bulletin·Rie ItoTakashi Suzuki
May 4, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Elena TeruiNaomi Ohnuma

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