PMID: 11905986Mar 22, 2002Paper

Neuronal storage of histamine in the brain and tele-methylimidazoleacetic acid excretion in portocaval shunted rats

Journal of Neurochemistry
W A FogelC Maslinski

Abstract

Rats with portocaval anastomosis (PCA), an animal model of hepatic encephalopathy (HE), have very high brain histamine concentrations. Our previous studies based on a biochemical approach indicated histamine accumulation in the neuronal compartment. In this study, immunohistochemical evidence is presented which further supports the amine localization in histaminergic neurons. These neurons become pathological in appearance with cisternae frequently seen along histaminergic fibres in many brain areas, including the hypothalamus, amygdala, substantia nigra and cerebral cortex. Such formations were not observed in sham-operated animals. The neuronal deposition is predominant, and unique for histamine. It serves as a mechanism to counterbalance excessive brain neurotransmitter formation evoked by PCA. However, there are other mechanisms. The data provided here show that there is also a significant increase in histamine catabolism in the shunted rats, as reflected by both the higher brain N-tele-methylhistamine (t-MeHA) concentration and urinary excretion of N-tele-methylimidazoleacetic acid (t-MelmAA), a major brain histamine end product. The stomach, in addition to the brain, is a site of enhanced histamine synthesis in portocaval...Continue Reading

Citations

Apr 1, 1995·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·W A FogelC Maslinski
Apr 11, 2014·CNS Neuroscience & Therapeutics·Wieslawa Agnieszka FogelMiroslaw Mussur
Dec 22, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Aurelio A Moya-GarciaFrancisca Sánchez-Jiménez
Jun 21, 2013·Nature Reviews. Neuroscience·Pertti Panula, Saara Nuutinen
Jul 16, 2008·Physiological Reviews·Helmut L HaasOliver Selbach
Sep 25, 2010·The Journal of Pharmacology and Experimental Therapeutics·Pertti Panula, Saara Nuutinen

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