Neuronally released vasoactive intestinal polypeptide alters atrial electrophysiological properties and may promote atrial fibrillation

Heart Rhythm : the Official Journal of the Heart Rhythm Society
Yutao XiJie Cheng

Abstract

Vagal hyperactivity promotes atrial fibrillation (AF), which has been almost exclusively attributed to acetylcholine. Vasoactive intestinal polypeptide (VIP) and acetylcholine are neurotransmitters co-released during vagal stimulation. Exogenous VIP has been shown to promote AF by shortening action potential duration (APD), increasing APD spatial heterogeneity, and causing intra-atrial conduction block. The purpose of this study was to investigate the effects of neuronally released VIP on atrial electrophysiologic properties during vagal stimulation. We used a specific VIP antagonist (H9935) to uncover the effects of endogenous VIP released during vagal stimulation in canine hearts. H9935 significantly attenuated (1) the vagally induced shortening of atrial effective refractory period and widening of atrial vulnerability window during stimulation of cervical vagosympathetic trunks (VCNS) and (2) vagal effects on APD during stimulation through fat-pad ganglion plexus (VGPS). Atropine completely abolished these vagal effects during VCNS and VGPS. In contrast, VGPS-induced slowing of local conduction velocity was completely abolished by either VIP antagonist or atropine. In pacing-induced AF during VGPS, maximal dominant frequenci...Continue Reading

References

Feb 1, 1991·Journal of Molecular and Cellular Cardiology·L V RosenshtraukhV I Krinsky
Jul 1, 1994·Journal of the Autonomic Nervous System·H KimuraY Nakazato
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·T W MoodyI Gozes
Oct 1, 1996·Journal of Cardiovascular Electrophysiology·P Coumel
Oct 17, 2002·Journal of Cardiovascular Electrophysiology·Masamichi HiroseKenneth R Laurita
Jul 5, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·David C RandallJeffrey L Ardell
Aug 17, 2005·Journal of Cardiovascular Electrophysiology·Mehdi RazaviJie Cheng
Apr 12, 2011·Respiratory Research·Dongmei WuYong Kiel Sung
Dec 12, 2012·Journal of Cardiovascular Electrophysiology·Jacques Billette, Rafik Tadros
Sep 21, 2013·Circulation. Arrhythmia and Electrophysiology·Yutao XiJie Cheng

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Citations

Oct 30, 2018·Journal of the American Heart Association·William A HuangMarmar Vaseghi

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