Neuronatin gene: Imprinted and misfolded: Studies in Lafora disease, diabetes and cancer may implicate NNAT-aggregates as a common downstream participant in neuronal loss

Genomics
Rajiv Madathiparambil Joseph

Abstract

Neuronatin (NNAT) is a ubiquitous and highly conserved mammalian gene involved in brain development. Its mRNA isoforms, chromosomal location, genomic DNA structure and regulation have been characterized. More recently there has been rapid progress in the understanding of its function in physiology and human disease. In particular there is fairly direct evidence implicating neuronatin in the causation of Lafora disease and diabetes. Neuronatin protein has a strong predisposition to misfold and form cellular aggregates that cause cell death by apoptosis. Aggregation of Neuronatin within cortical neurons and resulting cell death is the hallmark of Lafora disease, a progressive and fatal neurodegenerative disease. Under high glucose conditions simulating diabetes, neuronatin protein also accumulates and destroys pancreatic beta cells. The neuronatin gene is imprinted and only the paternal allele is normally expressed in the adult. However, changes in DNA methylation may cause the maternal allele to lose imprinting and trigger cell proliferation and metastasis. Neuronatin has also been shown to be translated peripherally within the dendrites of neurons, a finding of relevance in synaptic plasticity. The current understanding of the ...Continue Reading

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Citations

Apr 26, 2016·Neuroscience·Vishal ShindeMarina Gorbatyuk
Oct 8, 2016·Integrative Biology : Quantitative Biosciences From Nano to Macro·Kenta ShimbaYasuhiko Jimbo
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Jun 8, 2021·Cancer Biomarkers : Section a of Disease Markers·Willi PieperNorbert Nass
Jul 2, 2021·The Journal of Toxicological Sciences·Bingda LiYun Tu

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