Neurone-to-astrocyte signalling in the brain represents a distinct multifunctional unit

The Journal of Physiology
Tommaso Fellin, Giorgio Carmignoto

Abstract

Astrocytes can respond to neurotransmitters released at the synapse by generating elevations in intracellular Ca(2+) concentration ([Ca(2+)](i)) and releasing glutamate that signals back to neurones. This discovery opens new perspectives for the possible participation of these glial cells in actual information processing by the brain and raises the hypothesis that astrocyte activation by neuronal signals plays a key role in distinct, functional events. Depending on the level of neuronal activity, the [Ca(2+)](i) response that is activated by neurotransmitters can either remain restricted to an astrocytic process or it can propagate as an intracellular [Ca(2+)](i) wave to other astrocytic processes in contact with different neurones, astrocytes, microglia or endothelial cells of cerebral arterioles. Glutamate release triggered by the [Ca(2+)](i) rise at the astrocytic process represents a feedback, short-distance signal that affects synaptic transmission locally. The release of glutamate as well as of other compounds far away from the site of initial activation represents a feedforward, long-distance signal that can be involved in the regulation of distinct processes. For instance, through the release of vasoactive molecules fro...Continue Reading

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