Neurones in the ventrolateral pons are required for post-hypoxic frequency decline in rats

The Journal of Physiology
Sharon K Coles, T E Dick

Abstract

1. The breathing pattern following acute hypoxia (arterial O2 pressure (Pa,O2), 27.4 +/- 7.7 mmHg) was measured in intact, anaesthetized and spontaneously breathing adult rats (n = 4) and in anaesthetized, vagotomized, paralysed and ventilated animals (n = 14). Measurements were made both before and after bilateral lesions or chemical inactivation of neurones in the lateral pons. Respiratory motor activity was recorded as an index of the respiratory cycle. We tested the hypothesis that the ventrolateral pons is required for expression of post-hypoxic frequency decline, defined as a decrease in respiratory frequency below steady-state baseline levels following brief exposures to hypoxia. 2. We identified an area in the ventrolateral pons where brief (1 ms) low current (< or = 20 microA) pulses evoked a short-latency inhibitor of phrenic nerve activity. At this site, bilateral electrical or chemical lesions (n = 3) were performed, or neural activity was inhibited by focal injections of 10 mM muscimol (n = 9). In six control animals, neural activity was inhibited by muscimol injections into the lateral pons, dorsal to the target site. 3. Prior to pontine intervention, respiratory frequency decreased below baseline levels following...Continue Reading

Citations

Sep 23, 2014·Respiratory Physiology & Neurobiology·Paulina M GetsyStephen J Lewis
Sep 17, 2009·Cellular and Molecular Life Sciences : CMLS·Vincent Joseph, Jean-Marc Pequignot
Mar 4, 2000·The Journal of Physiology·M S SiniaiaC S Poon
Apr 17, 2002·The Journal of Physiology·R J A WilsonJ E Remmers
Jul 5, 2008·The Journal of Physiology·Thomas E DickKendall F Morris
Jun 12, 2012·Respiratory Physiology & Neurobiology·Hanan KhemiriJorge Soliz
Aug 1, 2009·Respiratory Physiology & Neurobiology·Thomas E DickKendall F Morris
Nov 11, 2008·Respiratory Physiology & Neurobiology·Gang Song, Chi-Sang Poon
Jun 14, 2008·Respiratory Physiology & Neurobiology·Luciane H GargaglioniLuiz Guilherme S Branco
Dec 2, 2006·Experimental Physiology·Thomas E DickNanduri Prabhakar
Nov 3, 2004·Respiratory Physiology & Neurobiology·Gang Song, Chi-Sang Poon
Nov 3, 2004·Respiratory Physiology & Neurobiology·Yee-Hsee HsiehThomas E Dick
Jun 20, 2006·Respiratory Physiology & Neurobiology·Shyamsunder SubramanianKingman P Strohl
Mar 13, 2010·Respiratory Physiology & Neurobiology·Joyce A Boon, William K Milsom
Dec 3, 2014·Respiratory Physiology & Neurobiology·Yee-Hsee HsiehThomas E Dick
Apr 18, 2013·PloS One·Alfredo J GarciaJan-Marino Ramirez
Mar 16, 2005·Respiratory Physiology & Neurobiology·Oleg Ilyinsky, Steve Mifflin
Jul 22, 2014·Open Journal of Molecular and Integrative Physiology·Walter J MayStephen J Lewis
Oct 17, 2003·Journal of Neurophysiology·Jean-Charles ViemariGérard Hilaire
Mar 6, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Thomas E DickNanduri Prabhakar
Nov 9, 2004·Journal of Applied Physiology·Francis J GolderGordon S Mitchell
Jan 29, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kevin J Cummings, Richard J A Wilson
Jun 24, 2000·The Japanese Journal of Physiology·F Hayashi, Y Fukuda
Dec 7, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yee-Hsee HsiehRuth E Siegel
Jul 18, 2008·Journal of Neurophysiology·Lauren S SegersBruce G Lindsey
Jun 6, 2012·Pflügers Archiv : European journal of physiology·Luana T LopesLuciane H Gargaglioni
Oct 16, 2012·Journal of Applied Physiology·J BernerR Wickstrom
Apr 16, 2010·Physiological Reviews·Luc J Teppema, Albert Dahan
Jun 25, 1998·The American Journal of Physiology·S K ColesT E Dick
Oct 29, 2000·Journal of Applied Physiology·K B Bach, G S Mitchell
Oct 20, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S RenolleauJ Gallego
May 31, 2002·Journal of Neurophysiology·Dawn M Blitz, Jan-Marino Ramirez
Aug 7, 2009·Journal of Neurophysiology·Kun-Ze LeeDavid D Fuller
Sep 14, 1999·The American Journal of Physiology·R Kinkead, G S Mitchell
Oct 23, 2002·Journal of Applied Physiology·Michelle McGuireLiming Ling
Oct 20, 2001·Journal of Applied Physiology·F HanK P Strohl

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.