Neurons and T cells: Understanding this interaction for inflammatory neurological diseases

European Journal of Immunology
Lidia YshiiRoland Liblau

Abstract

Central nervous system (CNS) inflammation occurs in a large number of neurological diseases. The type and magnitude of CNS inflammation, as well as the T-cell contribution, vary depending on the disease. Different animal models of neurological diseases have shown that T cells play an important role in CNS inflammation. Furthermore, recent studies of human neurological disorders have indicated a significant role for T cells in disease pathology. Nevertheless, how individual T-cell subsets affect neuronal survival, damage and/or loss remains largely unclear. In this review we discuss the processes by which T cells mediate either beneficial or deleterious effects within the CNS, with emphasis on the direct interaction between T cells and neurons, as occurs in multiple sclerosis, paraneoplastic cerebellar degeneration, and viral encephalitis. The therapeutic approaches targeting T cells and their mediators as treatment for neurological diseases are also described here.

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Citations

Mar 24, 2016·Brain : a Journal of Neurology·Abdulraouf RamadanLennart T Mars
Jul 29, 2016·European Journal of Immunology·Roland MartinBritta Engelhardt
Sep 14, 2016·Proceedings of the National Academy of Sciences of the United States of America·Raphaël Bernard-ValnetRoland S Liblau
Nov 9, 2016·The Journal of Experimental Medicine·Felix J HartmannBurkhard Becher
Apr 11, 2017·Journal of Neuropathology and Experimental Neurology·Jian-Qiang LuDonald W Gross
May 11, 2021·Frontiers in Immunology·Florent LemaîtreNathalie Arbour
Aug 19, 2021·Annals of Neurology·Raphaël Bernard-ValnetRenaud Du Pasquier

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