Neurons expressing the aryl hydrocarbon receptor in the locus coeruleus and island of Calleja major are novel targets of dioxin in the mouse brain.

Histochemistry and Cell Biology
Eiki KimuraChiharu Tohyama

Abstract

The aryl hydrocarbon receptor (AhR) acts as a receptor that responds to ligands, including dioxin. The AhR-ligand complex translocates from the cytoplasm into the nucleus to induce gene expression. Because dioxin exposure impairs cognitive and neurobehavioral functions, AhR-expressing neurons need to be identified for elucidation of the dioxin neurotoxicity mechanism. Immunohistochemistry was performed to detect AhR-expressing neurons in the mouse brain and confirm the specificity of the anti-AhR antibody using Ahr-/- mice. Intracellular distribution of AhR and expression level of AhR-target genes, Cyp1a1, Cyp1b1, and Ahr repressor (Ahrr), were analyzed by immunohistochemistry and quantitative RT-PCR, respectively, using mice exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). The mouse brains were shown to harbor AhR in neurons of the locus coeruleus (LC) and island of Calleja major (ICjM) during developmental period in Ahr+/+ mice but not in Ahr-/- mice. A significant increase in nuclear AhR of ICjM neurons but not LC neurons was found in 14-day-old mice compared to 5- and 7-day-old mice. AhR was significantly translocated into the nucleus in LC and ICjM neurons of TCDD-exposed adult mice. Additionally, the expression leve...Continue Reading

References

Sep 15, 1978·The Journal of Comparative Neurology·J H FallonR Y Moore
May 1, 1991·Brain Research. Molecular Brain Research·G MengodJ M Palacios
Jan 14, 1998·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·J MimuraY Fujii-Kuriyama
Sep 6, 2002·Chemico-biological Interactions·Mark E Hahn
Feb 8, 2003·Biochimica Et Biophysica Acta·Junsei Mimura, Yoshiaki Fujii-Kuriyama
May 12, 2004·Developmental Biology·Hongtao Qin, Jo Anne Powell-Coffman
May 28, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Malini E SinghPaul E Mallet
Jul 11, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Martin Van den BergRichard E Peterson
Dec 18, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stephanie MoriceauRegina M Sullivan
Sep 13, 2012·Nature Reviews. Neuroscience·John F Cryan, Timothy G Dinan
Nov 6, 2012·Brain Research·Yi-Chun Hsieh, Adam C Puche
Sep 6, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shingo SoyaTakeshi Sakurai
Dec 3, 2013·Archives of Toxicology·Masaki KakeyamaChiharu Tohyama
Jan 1, 1985·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·S A Bayer
Feb 18, 2015·The Journal of Clinical Investigation·Emeran A MayerArpana Gupta
May 15, 2016·Biochemical and Biophysical Research Communications·Eiki KimuraChiharu Tohyama
Sep 8, 2016·Nature·Tomonori TakeuchiRichard G M Morris
Feb 23, 2017·Frontiers in Neuroanatomy·Eiki Kimura, Chiharu Tohyama
Jan 21, 2018·Proceedings of the National Academy of Sciences of the United States of America·Ghjuvan'Ghjacumu ShacklefordCharbel Massaad
May 18, 2018·Nature·Veit RothhammerFrancisco J Quintana
Sep 5, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Isabel Bravo-FerrerMaría A Moro
Jan 8, 2021·Cellular & Molecular Immunology·Andreia BarrosoFrancisco J Quintana

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.