PMID: 8584267Nov 10, 1995Paper

Neurons, intracellular and extracellular neurofibrillary tangles in subdivisions of the hippocampal cortex in normal ageing and Alzheimer's disease

Neuroscience Letters
Y FukutaniN J Cairns

Abstract

Unaffected neurons, intracellular neurofibrillary tangles (I-NFTs) and extracellular NFTs (E-NFTs) in six normal subjects and six patients with Alzheimer's disease (AD) were morphometrically evaluated in eight subdivisions of the hippocampal cortex, using the Gallyas silver impregnation technique modified by the application of hematoxylin and eosin. The subdivisions examined included CA1-4, prosubiculum (PRO), subiculum and presubiculum (PRE), parasubiculum (PARA) and the entorhinal cortex (ENT). In the AD patients, the number of unaffected neurons in ENT, CA1, PRO and PARA was significantly decreased to one-quarter to two-thirds of that of the normal aged subjects. These four subdivisions in the AD patients had a greater number of both I- and E-NFTs. There were no significant differences in the total number of unaffected neurons, I- and ENTs between the AD patients and normal aged subjects for all the subdivisions. These findings suggest that neuronal loss in the hippocampal cortex in AD is almost entirely due to NFT formation. Furthermore, with regards to neuronal loss and NFT formation, there were two different subdivision groups in the AD patients. One group was composed of severely affected subdivisions (ENT, CA1, PRO and ...Continue Reading

Citations

Apr 2, 2014·Neurobiology of Aging·Laura E M WisseUNKNOWN Utrecht Vascular Cognitive Impairment (VCI) Study Group
Feb 13, 2001·Neurobiology of Aging·Y Ihara
Jul 17, 2010·The Journal of Biological Chemistry·Miguel Díaz-HernándezJesús Avila
Feb 6, 2007·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Martin GrunwaldHermann-Josef Gertz
Aug 6, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M Goedert
Oct 19, 2006·Journal of Biomedicine & Biotechnology·J AvilaF Moreno
Jun 26, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Donna M WilcockCarol A Colton
Oct 29, 2014·Acta Neuropathologica·John F CraryPeter T Nelson
Sep 2, 2004·Proceedings of the National Academy of Sciences of the United States of America·Kunlin JinDavid A Greenberg
Dec 9, 2003·Proceedings of the National Academy of Sciences of the United States of America·Kunlin JinDavid A Greenberg
Dec 24, 2008·Journal of Neuropathology and Experimental Neurology·Peter T NelsonWilliam R Markesbery
Apr 11, 2012·Journal of Neuropathology and Experimental Neurology·Peter T NelsonThomas G Beach
Jul 5, 2013·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Lynn M BekrisJames B Leverenz
Feb 25, 2015·Computational and Structural Biotechnology Journal·Álvaro Sebastián-SerranoMiguel Díaz-Hernández
Jan 7, 2014·Neurobiology of Aging·Natacha CoppietersMike Dragunow
Dec 24, 2014·Neurobiology of Aging·Pedro J ChacónAlfredo Rodríguez-Tébar
Aug 18, 2006·FEBS Letters·Alberto Gómez-RamosJesús Avila
Sep 15, 2010·Human Brain Mapping·Susanne G MuellerMichael W Weiner
Oct 31, 2018·Human Brain Mapping·Xiaoying TangMichael I Miller
May 29, 2019·Alzheimer Disease and Associated Disorders·Kaori HataHiroshi Matsuda
Sep 10, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Sandhitsu R DasUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jun 1, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Madepalli K LakshmanaTakeshi Tabira
Apr 25, 2020·Current Alzheimer Research·Adrianna WysockaGrazyna Niewiadomska
Apr 30, 2019·Human Brain Mapping·Long XieUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jan 20, 2020·Brain Structure & Function·Nicola Palomero-GallagherKatrin Amunts
Oct 27, 2018·Frontiers in Aging Neuroscience·Fenglian ZhengJianfeng Qiu
Dec 1, 2020·Journal of Alzheimer's Disease : JAD·Qingze ZengUNKNOWN The Alzheimer’s Disease Neuroimaging Initiative
Oct 16, 2020·Human Brain Mapping·Laura E M WisseValerie A Carr
Feb 22, 2021·Neuroscience Letters·Laura GilMaría E Jiménez-Capdeville

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.