Neuropathic and inflammatory antinociceptive effects and electrocortical changes produced by Salvia divinorum in rats

Journal of Ethnopharmacology
Karina Simón-ArceoFrancisco Pellicer

Abstract

Salvia divinorum is a medicinal plant traditionally used in hallucinogenic ethnopharmacological practices and for its analgesic and antinflammatory properties. Its active compounds include diterpenes known as salvinorins which act as potent κ opioid receptor agonists. Given its effects in acute animal models of pain, as well as its antinflammatory attributes, we decided to investigate the analgesic effects of an SD extract in neuropathic (sciatic loose nerve ligature) and inflammatory (intra plantar carrageenan) pain models in rats. We also determined in this study the electrocorticographic changes to correlate similar hallucinogenic state and behavior as those produced in humans. Mechanical and thermonociceptive responses, plantar test and von Frey assay, respectively, were measured in adult Wistar rats 30min, 3h and 24h after the intraperitoneal administration of saline or an hydroponic SD extract. We also evaluated carbamazepine and celecoxib, as gold reference drugs, to compare its antinociceptive effects. Our results showed that administration of SD extract induced antialgesic effects in both neuropathic and inflammatory pain models. All those effects were blocked by nor-binaltorphimine (a Kappa opioid receptor antagonist)...Continue Reading

References

Apr 19, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Gabriella AvielloRaffaele Capasso

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Citations

Oct 5, 2017·European Journal of Pain : EJP·U CoffeenF Pellicer
Nov 6, 2020·Journal of Ethnopharmacology·Moreno-Pérez FernandoGonzález-Trujano María Eva
Dec 6, 2019·Peptides·Richard J Bodnar
Feb 7, 2021·Pharmaceuticals·Andreia Machado Brito-da-CostaÁurea Madureira-Carvalho

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