Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment

Lancet Neurology
Ralf BaronGunnar Wasner

Abstract

Neuropathic pain develops as a result of lesions or disease affecting the somatosensory nervous system either in the periphery or centrally. Examples of neuropathic pain include painful polyneuropathy, postherpetic neuralgia, trigeminal neuralgia, and post-stroke pain. Clinically, neuropathic pain is characterised by spontaneous ongoing or shooting pain and evoked amplified pain responses after noxious or non-noxious stimuli. Methods such as questionnaires for screening and assessment focus on the presence and quality of neuropathic pain. Basic research is enabling the identification of different pathophysiological mechanisms, and clinical assessment of symptoms and signs can help to determine which mechanisms are involved in specific neuropathic pain disorders. Management of neuropathic pain requires an interdisciplinary approach, centred around pharmacological treatment. A better understanding of neuropathic pain and, in particular, of the translation of pathophysiological mechanisms into sensory signs will lead to a more effective and specific mechanism-based treatment approach.

Associated Clinical Trials

References

Dec 11, 1981·Neuroscience Letters·B Nyström, K E Hagbarth
Nov 10, 1998·Pain·C J WoolfE Torebjork
Apr 3, 2001·Annual Review of Neuroscience·M J Caterina, D Julius
Jun 19, 2001·Pain·M C Rowbotham, K L Petersen
Feb 5, 2003·Brain : a Journal of Neurology·Kristin ØrstavikErik Torebjörk
Jul 10, 2003·Current Opinion in Neurobiology·Josephine LaiFrank Porreca
Jan 30, 2004·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·N B Finnerup, T S Jensen
Feb 27, 2004·Brain : a Journal of Neurology·Gunnar WasnerRalf Baron
Mar 20, 2004·Pain·Didier BouhassiraFrançois Boureau
May 21, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bryan C HainsStephen G Waxman
Jul 28, 2004·Pain·Peter Vestergaard RasmussenFlemming Winther Bach
Feb 4, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Beth B MurinsonJohn W Griffin
Mar 11, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ron AmirMarshall Devor
Mar 22, 2005·Journal of Neurology·Gunnar WasnerRalf Baron
Apr 1, 2005·The New England Journal of Medicine·Ian GilronRobyn L Houlden
Apr 9, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Parmvir K BahiaGuy W J Moss
Apr 27, 2005·Anesthesiology·Nanna B FinnerupTroels S Jensen
Jun 3, 2005·The New England Journal of Medicine·M N OxmanUNKNOWN Shingles Prevention Study Group
Jun 11, 2005·Brain : a Journal of Neurology·H BostockJ L Ochoa
Jun 24, 2005·The New England Journal of Medicine·J Kenneth Baillie, Ian Power
Aug 12, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Joachim ScholzClifford J Woolf
Jan 26, 2006·Brain : a Journal of Neurology·Denis DucreuxDidier Bouhassira
Aug 26, 2006·Nature Clinical Practice. Neurology·Ralf Baron
Nov 3, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kristin ØrstavikH Erik Torebjörk
Dec 22, 2006·Pain·Michael I BennettTroels Staehelin Jensen
Mar 21, 2007·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·D E MoulinUNKNOWN Canadian Pain Society
Jul 6, 2007·The European Journal of Neuroscience·Michael J M Fischer, Peter W Reeh
Jul 10, 2007·Progress in Brain Research·Bryan C Hains, Stephen G Waxman
Aug 28, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G CruccuR S Taylor
Oct 30, 2007·Nature Neuroscience·Joachim Scholz, Clifford J Woolf

❮ Previous
Next ❯

Citations

Mar 1, 2012·Der Schmerz·C Maier, R Baron
Apr 12, 2011·Hernia : the Journal of Hernias and Abdominal Wall Surgery·G LinderothM U Werner
May 9, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Jaehyung KimJin Woo Chang
May 25, 2012·Current Diabetes Reports·Elena K KrumovaChristoph Maier
May 17, 2013·Current Diabetes Reports·Vincenza Spallone, Carla Greco
Aug 15, 2013·Current Pain and Headache Reports·Yelena Granovsky
Sep 3, 2013·Current Pain and Headache Reports·Marieke BiegstraatenCarla E M Hollak
Sep 3, 2013·Current Pain and Headache Reports·Yuko Kanbayashi, Toyoshi Hosokawa
Aug 15, 2013·Neuroscience Letters·Wahida Rahman, Anthony H Dickenson
May 26, 2011·British Journal of Anaesthesia·G Niraj, D J Rowbotham
Nov 10, 2011·Brain : a Journal of Neurology·David Borsook
Mar 31, 2012·The Nurse Practitioner·Margaret Hammersla, Jane Faith Kapustin
Apr 2, 2011·Regional Anesthesia and Pain Medicine·Henning HermannsInge Bauer
Jan 3, 2012·The Clinical Journal of Pain·Vincenza SpallonePaolo Marchettini
Jan 3, 2012·The Clinical Journal of Pain·Yuko KanbayashiToyoshi Hosokawa
May 9, 2012·Pediatric Emergency Care·Muhammad WaseemKonstantin Dobrenkov
Apr 18, 2013·Practical Neurology·Francesca MagrinelliStefano Tamburin
Nov 24, 2011·Pain Research and Treatment·Bishnu Subedi, George T Grossberg
Nov 24, 2011·Pain Research and Treatment·Yu HuangWanhong Liu
Aug 2, 2011·Biological & Pharmaceutical Bulletin·Hiroshi Ueda
Jul 12, 2013·PloS One·Matti FörsterRalf Baron
Oct 12, 2012·Journal of Pain Research·Joseph V PergolizziRobert B Raffa
Jan 10, 2012·American Journal of Clinical Dermatology·Ashley R CurtisGil Yosipovitch
Mar 10, 2012·The Journal of Orthopaedic and Sports Physical Therapy·Robert J NeeMichel W Coppieters
Dec 24, 2013·Journal of Tissue Viability·Antonia Jelicic KadicLivia Puljak
Feb 19, 2014·Nature Reviews. Neurology·Mark P JensenJordi Miró
Feb 28, 2014·Postgraduate Medical Journal·Danielle Reddi, Natasha Curran
Aug 21, 2013·Cardiovascular and Interventional Radiology·Yilun KoetheBradford J Wood
Jun 24, 2014·Pain Management·Clara Sm WongSteven Hs Wong

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

© 2021 Meta ULC. All rights reserved