Neuropathic pain in leprosy

Clinics in Dermatology
Irina RaicherDaniel Ciampi de Andrade

Abstract

Nerve impairment is a key clinical aspect of leprosy and may present the distribution of mononeuropathy or multiple nerve trunks, small cutaneous nerve fibers, and free nerve endings. The clinical range of leprosy is determined by individual cell-mediated immune response to infection that also may play a role in different types of pain syndromes in leprosy. Previous studies reported a high prevalence of neuropathic pain in leprosy. In an Ethiopian study with 48 patients, pure nociceptive pain was experienced by 43% of patients and pure neuropathic pain (NeP) by 11% of patients. In an Indian study, 21.8% of leprosy patients had pain with neuropathic characteristics. These rates underlie the need to develop tools for the early diagnosis and detection of infection and its complications, such as nerve damage and pain. In a larger sample with leprosy-associated NeP (n = 90), we have applied the Douleur Neuropathique en 4 questions (DN4) and found sensitivity = 97.1% and specificity = 57.9%. The high sensitivity of this tool in leprosy patients suggests that it could be a valuable tool to screen for neuropathic pain in this population and could be used as part of health care programs aimed at detecting, treating, and rehabilitating l...Continue Reading

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Citations

Jan 17, 2016·Clinics in Dermatology·Andrzej Grzybowski, Marcos Virmond
Apr 4, 2018·The American Journal of Tropical Medicine and Hygiene·Louise Mara GieselMarcia Maria Jardim Rodrigues
Jul 3, 2018·PLoS Neglected Tropical Diseases·Han-Siong TohDiana N J Lockwood
May 10, 2017·The Clinical Journal of Pain·Elizabeth G VanDenKerkhofDwight E Moulin
Oct 31, 2017·Neuromodulation : Journal of the International Neuromodulation Society·Tiago da Silva FreitasMonalisa Ferreira Azevedo
Feb 11, 2020·Frontiers in Immunology·Débora Bartzen Moraes AngstMárcia Rodrigues Jardim
Apr 2, 2020·Journal of the American Academy of Dermatology·Mayra B C MaymoneCory A Dunnick
Aug 25, 2021·BMC Infectious Diseases·Louise Mara GieselMarcia Rodrigues Jardim

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