Neuropathic Pain: Sensory Nerve Injury or Motor Nerve Injury?

Advances in Experimental Medicine and Biology
Xian-Guo LiuYing Zang

Abstract

Peripheral nerve injury often induces chronic neuropathic pain. Peripheral nerve is consisted of sensory fibers and motor fibers, it is questioned injury to which type of fibers is responsible for generation of neuropathic pain? Because neuropathic pain is sensory disorder, it is generally believed that the disease should be induced by injury to sensory fibers. In recent years, however, emergent evidence shows that motor fiber injury but not sensory fiber injury is necessary and sufficient for induction of neuropathic pain. Motor fiber injury leads to neuropathic pain by upregulating pro-inflammatory cytokines and brain-derived neurotrophic factor in pain pathway.

Citations

Mar 16, 2017·Journal of Neuroinflammation·Jinjie WuYanchun Liang
Mar 7, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Maria Raffaella BarbaroGiovanni Barbara
Nov 29, 2020·Neurochemistry International·Lanxin LuoDandan Sun
Jun 20, 2021·Regional Anesthesia and Pain Medicine·Ki Jinn ChinMiguel A Reina

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