Neuropathic Pain: the Dysfunction of Drp1, Mitochondria, and ROS Homeostasis.

Neurotoxicity Research
Chun-Qiu DaiXue-Yan Chu

Abstract

Neuropathic pain affects the physical and mental health status of patients. Due to its complex pathogenesis and the adverse reactions to medicines, its treatment remains challenging. Among all the etiologies, increasing evidence has pointed to mitochondrial dysfunction. Dynamin-related protein 1 (Drp1)-mediated mitochondrial fragmentation leads to excess ROS generation, which is implicated in the pathogenesis of neuropathic pain. However, the exact mechanism remains unclear. Studies aiming to clarify the possible pathway and relationship between Drp1, mitochondria, ROS, and neuropathic pain may identify a good treatment for neuropathic pain in the clinic. As shown in this review, dysfunction of Drp1 and ROS homeostasis plays essential roles in neuropathic pain. We summarized a Drp1-mitochondrial fission-ROS cycle that potentially functions in neuropathic pain and is regulated by posttranslational modifications and Ca2+. Additionally, we further enumerated six Drp1 inhibitors, including Mdivi-1, P110, Drp1 antisense oligodeoxynucleotides, hyperbaric oxygen, melatonin, and β-hydroxybutyrate, as potential treatments, with the aim of providing guidance for novel molecules to be used in the clinic.

References

Aug 22, 2001·Molecular Biology of the Cell·E SmirnovaA M van der Bliek
Jan 5, 2002·Physiological Reviews·Wulf Dröge
Dec 25, 2002·The Journal of Cell Biology·Mariusz KarbowskiRichard J Youle
Dec 16, 2006·The EMBO Journal·Rajesh RamachandranSandra L Schmid
Jun 8, 2007·The Journal of Biological Chemistry·Chuang-Rung Chang, Craig Blackstone
Oct 2, 2007·EMBO Reports·Arezu Jahani-Asl, Ruth S Slack
Jul 31, 2008·Developmental Neurobiology·Mandana Amiri, Peter J Hollenbeck
Oct 8, 2008·Proceedings of the National Academy of Sciences of the United States of America·G M CereghettiL Scorrano
Dec 9, 2008·The Biochemical Journal·Michael P Murphy
Dec 17, 2008·Annals of the New York Academy of Sciences·Anatoly A Starkov
Oct 23, 2009·Diabetologia·J L EdwardsE L Feldman
Jul 24, 2010·Annals of the New York Academy of Sciences·Chuang-Rung Chang, Craig Blackstone
Dec 15, 2010·Brain Research Reviews·P Hemachandra ReddyPeizhong Mao
Apr 22, 2011·EMBO Reports·Catherine S PalmerMichael T Ryan
Jul 19, 2011·Pain·Troels S JensenRolf-Detlef Treede
Aug 5, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Luiz F FerrariJon D Levine
Sep 20, 2011·Nature·Marijn G J FordJodi Nunnari
Jan 31, 2012·Cellular Signalling·Paul D RayYoshiaki Tsuji
Feb 16, 2012·The Journal of Biological Chemistry·Stefan Strack, J Thomas Cribbs
Dec 15, 2012·Journal of Cell Science·Xin QiDaria Mochly-Rosen
Feb 26, 2013·Biochimica Et Biophysica Acta·Hidenori OteraKatsuyoshi Mihara
Oct 1, 2013·Lancet Neurology·Ian GilronAnthony H Dickenson
Nov 5, 2013·Antioxidants & Redox Signaling·Jin O-UchiShey-Shing Sheu
Dec 7, 2013·The New England Journal of Medicine·Stephen L Archer
Dec 12, 2013·Biochimica Et Biophysica Acta·Hiromi SesakiMiho Iijima
Feb 7, 2014·BMJ : British Medical Journal·Steven P Cohen, Jianren Mao
Jul 6, 2014·Physiological Reviews·Dmitry B ZorovSteven J Sollott
Jan 13, 2015·Lancet Neurology·Nanna B FinnerupMark Wallace
Apr 7, 2015·Mayo Clinic Proceedings·Ian GilronTroels Jensen
Jul 15, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Lara GibelliniMarcello Pinti
Oct 24, 2015·Neurobiology of Disease·A M BertholetP Belenguer
Jan 29, 2016·Current Neuropharmacology·Aparna AretiAshutosh Kumar
Jul 1, 2014·Molecular & Cellular Oncology·Müge Ogrunc
Oct 28, 2016·Apoptosis : an International Journal on Programmed Cell Death·Rostyslav Horbay, Rostyslav Bilyy
Oct 6, 2016·Seminars in Neurology·Janne Gierthmühlen, Ralf Baron

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Citations

Apr 4, 2021·International Journal of Molecular Sciences·Bong Hyo LeeYoung S Gwak
Mar 21, 2021·FEBS Letters·Nethmi M B YapaMichael T Ryan

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Methods Mentioned

BETA
GTPase
ubiquitination
antisense oligodeoxynucleotide

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