Neuropathologic analysis of hematomas evacuated from patients with spontaneous intracerebral hemorrhage

Neuropathology : Official Journal of the Japanese Society of Neuropathology
Justin A DyeH V Vinters

Abstract

Spontaneous intracerebral hemorrhage (ICH) is a devastating cause of morbidity and mortality. Intraparenchymal hematomas are often surgically evacuated. This generates fragments of perihematoma brain tissue that may elucidate their etiology. The goal of this study is to analyze the value of these specimens in providing a possible etiology for spontaneous ICH as well as the utility of using immunohistochemical markers to identify amyloid angiopathy. Surgically resected hematomas from 20 individuals with spontaneous ICH were examined with light microscopy. Hemorrhage locations included 11 lobar and nine basal ganglia hemorrhages. Aβ immunohistochemistry and Congo red stains were used to confirm the presence of amyloid angiopathy, when this was suspected. Evidence of cerebral amyloid angiopathy (CAA) was observed in eight of the 20 specimens, each of which came from lobar locations. Immunohistochemistry confirmed CAA in the brain fragments from these eight individuals. Patients with immunohistochemically confirmed CAA were older than patients without CAA, and more likely to have lobar hemorrhages (OR 3.0 and 3.7, respectively). Evidence of CAA was not found in any of the basal ganglia specimens. One specimen showed evidence of CAA...Continue Reading

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Citations

May 6, 2016·Neuropathology : Official Journal of the Japanese Society of Neuropathology·José E H Pittella, Sebastião N da Silva Gusmão
Feb 6, 2018·Current Treatment Options in Neurology·Thomas J CusackWendy C Ziai
Dec 6, 2018·Continuum : Lifelong Learning in Neurology·Wendy C Ziai, J Ricardo Carhuapoma
Apr 18, 2020·Journal of the American College of Cardiology·Matthew Schrag, Howard Kirshner
Jul 31, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Shino MagakiHarry V Vinters
Oct 3, 2021·Current Neurology and Neuroscience Reports·Howard Kirshner, Matthew Schrag

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