Neuropathologic aspects of hypothermic circulatory arrest in newborn dogs

Acta Neuropathologica
D J MujsceR C Vannucci

Abstract

A model of hypothermic circulatory arrest with recovery has been developed in the newborn dog. Eleven puppies were anesthetized with halothane, paralyzed and artificially ventilated with 70% nitrous oxide -30% oxygen to paO2 > 60 mm Hg, paCO2 = 33-42 mm Hg and pHa = 7.35-7.42. Animals were surface cooled to 20 degrees C, following which cardiac arrest was effected with i.v. KCl. Dogs remained asystolic without ventilation for 1.0, 1.5 or 1.75. Resuscitation was accomplished with closed-chest compression, mechanical ventilation, i.v. epinephrine and NaHCO3, and rewarming to 37 degrees C. Thereafter, the puppies were allowed to recover from anesthesia and maintained for either 18-22 h (n = 9) or 72 h (n = 2), at which time they underwent perfusion-fixation of their brains for pathologic analysis. Of the total, four out of four puppies arrested for 1.0 h exhibited no brain damage, including one recovered for 72 h; whereas one out of three and four out of four puppies arrested for 1.5 and 1.75 h, respectively, showed brain damage predominantly of the cerebral cortex but also of the basal ganglia and amygdaloid nucleus. The hippocampus was spared, even in a 1.75-h-arrested animal which was maintained for 72 h. No differences in pre-...Continue Reading

Citations

Jul 1, 1995·The Journal of Thoracic and Cardiovascular Surgery·C L FilgueirasR Deslauriers
Mar 31, 1999·Seminars in Pediatric Neurology·R C Vannucci, J Towfighi
Mar 31, 1999·Seminars in Pediatric Neurology·A J du Plessis
Dec 14, 1999·The Journal of Thoracic and Cardiovascular Surgery·C D KurthR Raghupathi
Jul 27, 1999·The Annals of Thoracic Surgery·S M LangleyR M Ungerleider
Aug 24, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A M BrambrinkR J Traystman
Jan 13, 1997·The Journal of Comparative Neurology·L J MartinR J Traystman
Apr 29, 2005·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Dominique Shum-TimRobert Platt

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