PMID: 9447447Jan 1, 1997Paper

Neuropathological assessment of Alzheimer's disease: the experience of the Consortium to Establish a Registry for Alzheimer's Disease

International Psychogeriatrics
S S Mirra

Abstract

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD), a multicenter longitudinal study, has worked to establish standardized instruments for the evaluation of individuals clinically diagnosed as having Alzheimer's disease (AD). Since its formation in 1986, clinical neuropsychological, neuroimaging, and neuropathology assessment batteries have been developed. The neuropathology protocol not only establishes levels of certainty for the diagnosis of AD, but also facilitates correlations with clinical, genetic, and other data. We find a high rate of diagnostic accuracy: the clinical diagnosis of AD was confirmed in 176 of 201 (87.6%) CERAD dementia subjects. Coexistent vascular lesions, usually infarcts, were found in 32% of these confirmed AD cases, and 23% had coexisting Parkinson's disease (PD) changes (nigral degeneration and Lewy bodies at any site). In the remaining 25 cases (12.4%), neuropathologists attributed the primary cause of dementia to other conditions. In studies comparing neuropathology protocols for AD, several groups have found that the CERAD diagnosis most closely correlates with measures of dementia severity, such as the Mini-Mental State Examination (MMSE). Others have adopted the CERAD neuro...Continue Reading

Citations

Jul 10, 2001·Aging : Clinical and Experimental Research·F Boller, G D Barba
Jan 30, 2004·Annual Review of Medicine·John Hardy
Sep 25, 2018·European Journal of Clinical Investigation·Sally HunterCarol Brayne
Nov 10, 2009·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Andrea C BozokiRoderick J Little
Apr 14, 2020·Journal of Alzheimer's Disease : JAD·Sally HunterUNKNOWN Cambridge City over 75s Cohort collaboration
May 22, 2018·Journal of Alzheimer's Disease : JAD·Sally HunterCarol Brayne
Oct 19, 2000·Journal of the American Geriatrics Society·C BeckG W Small
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