PMID: 9164688May 1, 1997Paper

Neuropathological changes in chronic adult hydrocephalus: cortical biopsies and autopsy findings

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
M R Del BigioW C Halliday

Abstract

The cortical changes resulting from chronic hydrocephalus in adults are not well defined. Retrospective analysis of twenty-one patients (age 64-88 years) with a clinical diagnosis of "normal pressure hydrocephalus" who underwent cortical biopsy at the time of intracranial pressure monitoring or shunt insertion, and eight patients who were biopsied but not shunted. Eleven brains (age 26-92 years), seven from patients who could be considered to have "normal pressure hydrocephalus", were also examined following autopsy. Age- and sex-matched control brains with small ventricles and no history of dementia were compared to the hydrocephalic brains. Senile plaques and neurofibrillary tangles were assessed semiquantitatively and a non-parametric statistical analysis was employed. Five biopsies exhibited both senile plaques and rare neurofibrillary tangles, while two had only neurofibrillary tangles. Neurofibrillary tangles were more prevalent in hydrocephalic brains than in controls. There was no difference in the prevalence of senile plaques between the two groups. Grumose bodies in the substantia nigra were identified in five autopsy brains, a prevalence higher than in control brains. These pathological features are not specific for ...Continue Reading

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Citations

May 23, 2019·Frontiers in Aging Neuroscience·Jadwiga Attier-ZmudkaOlivier Balédent
Sep 28, 2004·Brain Pathology·Marc R Del Bigio
Jun 2, 2006·Cerebrospinal Fluid Research·Gerald SilverbergDawn McGuire
May 29, 2010·Cerebrospinal Fluid Research·James P McAllister, Janet M Miller
Jun 24, 2011·Neuropathology and Applied Neurobiology·V LeinonenI Alafuzoff
Oct 22, 2011·AJNR. American Journal of Neuroradiology·T HattoriH Mizusawa
Nov 15, 2011·AJNR. American Journal of Neuroradiology·T HattoriH Mizusawa
Nov 7, 2015·AJNR. American Journal of Neuroradiology·N FattahiJ Huston
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Oct 6, 2006·Cerebrospinal Fluid Research·Andrew TarnarisNeil D Kitchen
May 10, 2008·Journal of Neurosurgery·Michael A WilliamsGiovanna Spinella
Jun 20, 2017·Neuropathology and Applied Neurobiology·P K Eide, H-A Hansson
Jul 5, 2011·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Danielle CabralMarwan N Sabbagh
Jul 22, 2016·PloS One·Yi YangCarsten Wikkelsö
Feb 16, 2018·Journal of Neurosurgical Sciences·I Jonathan PomeraniecM Beatriz Lopes
Mar 25, 2019·Dementia and Neurocognitive Disorders·Min Ju KangSangHak Yi
Jun 7, 2019·Journal of Neurology, Neurosurgery, and Psychiatry·Anna JeppssonMats Tullberg
Nov 13, 2017·Journal of Neurology·Hyemin JangDuk L Na
Apr 27, 2010·Developmental Disabilities Research Reviews·Marc R Del Bigio

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