PMID: 1759558Jan 1, 1991Paper

Neuropathological stageing of Alzheimer-related changes

Acta Neuropathologica
H Braak, E Braak


Eighty-three brains obtained at autopsy from nondemented and demented individuals were examined for extracellular amyloid deposits and intraneuronal neurofibrillary changes. The distribution pattern and packing density of amyloid deposits turned out to be of limited significance for differentiation of neuropathological stages. Neurofibrillary changes occurred in the form of neuritic plaques, neurofibrillary tangles and neuropil threads. The distribution of neuritic plaques varied widely not only within architectonic units but also from one individual to another. Neurofibrillary tangles and neuropil threads, in contrast, exhibited a characteristic distribution pattern permitting the differentiation of six stages. The first two stages were characterized by an either mild or severe alteration of the transentorhinal layer Pre-alpha (transentorhinal stages I-II). The two forms of limbic stages (stages III-IV) were marked by a conspicuous affection of layer Pre-alpha in both transentorhinal region and proper entorhinal cortex. In addition, there was mild involvement of the first Ammon's horn sector. The hallmark of the two isocortical stages (stages V-VI) was the destruction of virtually all isocortical association areas. The investi...Continue Reading

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Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Apr 1, 1990·Neuropathology and Applied Neurobiology·B M HubbardJ M Anderson
May 7, 1990·Brain Research·W G TourtellotteA R Damasio
Jan 1, 1990·Progress in Brain Research·G W Van Hoesen, B T Hyman
Jan 1, 1988·Neuropathology and Applied Neurobiology·H Braak, E Braak
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Nov 1, 1989·Journal of Neuropathology and Experimental Neurology·H M WísniewskiW Silverman
Nov 1, 1989·Journal of the Neurological Sciences·H BraakW Lang
Jan 1, 1989·Acta Neuropathologica·H BraakP Kalus
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Nov 1, 1985·Archives of Neurology·Z S Khachaturian
Feb 12, 1988·Deutsche medizinische Wochenschrift·F GrünwaldH J Biersack
Dec 1, 1986·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·F Gallyas, J R Wolff
Feb 26, 1986·Brain Research·M M EsiriT P Powell
Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R C PearsonT P Powell
Nov 1, 1982·Journal of the Neurological Sciences·G K Wilcock, M M Esiri

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