PMID: 1759558Jan 1, 1991Paper

Neuropathological stageing of Alzheimer-related changes

Acta Neuropathologica
H Braak, E Braak

Abstract

Eighty-three brains obtained at autopsy from nondemented and demented individuals were examined for extracellular amyloid deposits and intraneuronal neurofibrillary changes. The distribution pattern and packing density of amyloid deposits turned out to be of limited significance for differentiation of neuropathological stages. Neurofibrillary changes occurred in the form of neuritic plaques, neurofibrillary tangles and neuropil threads. The distribution of neuritic plaques varied widely not only within architectonic units but also from one individual to another. Neurofibrillary tangles and neuropil threads, in contrast, exhibited a characteristic distribution pattern permitting the differentiation of six stages. The first two stages were characterized by an either mild or severe alteration of the transentorhinal layer Pre-alpha (transentorhinal stages I-II). The two forms of limbic stages (stages III-IV) were marked by a conspicuous affection of layer Pre-alpha in both transentorhinal region and proper entorhinal cortex. In addition, there was mild involvement of the first Ammon's horn sector. The hallmark of the two isocortical stages (stages V-VI) was the destruction of virtually all isocortical association areas. The investi...Continue Reading

Associated Clinical Trials

Jun 28, 2011·Gary Small, MD, Gary Small, MD

References

Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Apr 1, 1990·Neuropathology and Applied Neurobiology·B M HubbardJ M Anderson
May 7, 1990·Brain Research·W G TourtellotteA R Damasio
Jan 1, 1990·Progress in Brain Research·G W Van Hoesen, B T Hyman
Jan 1, 1988·Neuropathology and Applied Neurobiology·H Braak, E Braak
Jan 1, 1989·Neuropathology and Applied Neurobiology·H Braak, E Braak
Nov 1, 1989·Journal of Neuropathology and Experimental Neurology·H M WísniewskiW Silverman
Nov 1, 1989·Journal of the Neurological Sciences·H BraakW Lang
Jan 1, 1989·Acta Neuropathologica·H BraakP Kalus
Nov 1, 1989·Neurobiology of Aging·W BondareffD L Hauser
Nov 1, 1985·Archives of Neurology·Z S Khachaturian
Feb 12, 1988·Deutsche medizinische Wochenschrift·F GrünwaldH J Biersack
Dec 1, 1986·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·F Gallyas, J R Wolff
Feb 26, 1986·Brain Research·M M EsiriT P Powell
Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R C PearsonT P Powell
Nov 1, 1982·Journal of the Neurological Sciences·G K Wilcock, M M Esiri

❮ Previous
Next ❯

Citations

Jul 7, 2010·Archives of General Psychiatry·Madhav ThambisettySimon Lovestone
Nov 9, 2011·Archives of General Psychiatry·Anand KumarGary W Small
Aug 19, 2007·Archives of Neurology·Jennifer L WhitwellClifford R Jack
Jan 14, 2009·Archives of Neurology·Joshua A SonnenSuzanne Craft
May 13, 2009·Archives of Neurology·Milos D IkonomovicSteven T Dekosky
Jun 15, 2011·Archives of Neurology·Linda D NelsonGary W Small
Aug 10, 2011·Archives of Neurology·Mert R SabuncuUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Mar 16, 2011·Archives of Neurology·Robert S WilsonDavid A Bennett
Jul 25, 2012·Archives of Neurology·Paul T KotzbauerJoel S Perlmutter
Feb 15, 2013·JAMA Neurology·Debby TsuangCyrus P Zabetian
Nov 24, 1999·Hippocampus·S R Schultz, E T Rolls
Mar 30, 2000·Journal of Magnetic Resonance Imaging : JMRI·A BrunettiB Alfano
Mar 11, 1999·Annals of Neurology·J L Price, J C Morris
Aug 6, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·C D Hardman, G M Halliday
Mar 29, 2002·American Journal of Medical Genetics·Liisa MyllykangasPentti J Tienari
Nov 25, 2004·Annals of Neurology·Laura ParkkinenIrina Alafuzoff
Dec 29, 2004·Annals of Neurology·Glenda M HallidayJillian J Kril
Sep 28, 1998·Annals of Neurology·T J MontineL J Roberts
Jan 17, 2002·The Journal of Comparative Neurology·Elliott J MufsonJeffrey H Kordower
Dec 24, 1997·Journal of Magnetic Resonance Imaging : JMRI·N C Fox, P A Freeborough
Dec 18, 2001·Journal of Neuroscience Research·S R Robinson
Dec 5, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Irene Hegeman RichardRoger Kurlan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.