Neuropathologically mixed Alzheimer's and Lewy body disease: burden of pathological protein aggregates differs between clinical phenotypes

Acta Neuropathologica
Lauren WalkerJohannes Attems

Abstract

Multiple different pathological protein aggregates are frequently seen in human postmortem brains and hence mixed pathology is common. Mixed dementia on the other hand is less frequent and neuropathologically should only be diagnosed if criteria for more than one full blown disease are met. We quantitatively measured the amount of hyperphosphorylated microtubule associated tau (HP-τ), amyloid-β protein (Aβ) and α-synuclein (α-syn) in cases that were neuropathologically diagnosed as mixed Alzheimer's disease (AD) and neocortical Lewy body disease (LBD) but clinically presented either as dementia due to AD or LBD, the latter including dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD). Our study group consisted of 28 cases (mean age, 76.11 SE: ±1.29 years; m:f, 17:11) of which 19 were neuropathologically diagnosed as mixed AD/DLB. Clinically, 8 mixed AD/DLB cases were diagnosed as AD (cAD), 8 as DLB (cDLB) and 3 as PDD (cPDD). In addition, we investigated cases that were both clinically and neuropathologically diagnosed as either AD (pure AD; n = 5) or DLB/neocortical LBD (pure DLB; n = 4). Sections from neocortical, limbic and subcortical areas were stained with antibodies against HP-τ, Aβ and α-syn. The area...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Mar 1, 1985·Neurology·J L CummingsS Read
May 1, 1993·Journal of Neuropathology and Experimental Neurology·M S PollanenC Bergeron
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·W J StrittmatterA D Roses
Mar 31, 1998·Archives of Neurology·D Blacker, R E Tanzi
Apr 23, 1999·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·F ColletteE Salmon
Mar 16, 2002·Journal of Neuropathology and Experimental Neurology·Dietmar Rudolf ThalHeiko Braak
Nov 2, 2002·Dementia and Geriatric Cognitive Disorders·Andrew B SingletonChristopher M Morris
Nov 16, 2002·Archives of Neurology·Ron BrookmeyerClaudia Kawas
Dec 10, 2002·Acta Neuropathologica·Kurt A Jellinger, Johannes Attems
Dec 25, 2002·Neurobiology of Aging·Heiko BraakEva Braak
May 2, 2003·Journal of Neuropathology and Experimental Neurology·Takashi IshizawaDennis W Dickson
May 2, 2003·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Michael SerbyKenneth L Davis
May 7, 2005·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Richard A ArmstrongNigel J Cairns
May 11, 2005·Archives of Neurology·Mary GanguliSteven T DeKosky
Oct 21, 2005·Neurology·I G McKeithUNKNOWN Consortium on DLB
Jan 13, 2006·Brain : a Journal of Neurology·Pietro TiraboschiJody Corey-Bloom
Jun 29, 2006·Acta Neuropathologica·Kurt A Jellinger, Johannes Attems
Jul 11, 2006·Journal of Neuropathology and Experimental Neurology·Hirotake UchikadoDennis W Dickson
Feb 8, 2007·Acta Neuropathologica·Kurt A Jellinger
Feb 28, 2007·Journal of the Neurological Sciences·K A Jellinger, J Attems
Mar 14, 2007·Neurology·C F LippaUNKNOWN DLB/PDD Working Group
Jun 2, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Murat EmreBruno Dubois
Jun 17, 2008·Acta Neuropathologica·Hiroshige FujishiroDennis W Dickson
Jul 26, 2008·Journal of Neurology, Neurosurgery, and Psychiatry·P EdisonD J Brooks
Oct 14, 2008·Dementia and Geriatric Cognitive Disorders·Gabor G KovacsHerbert Budka
Feb 3, 2009·Acta Neuropathologica·Irina AlafuzoffHans Kretzschmar
Apr 22, 2009·Acta Neuropathologica·Charles DuyckaertsMarie-Claude Potier
Jan 1, 2007·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Kurt A Jellinger
Mar 6, 2010·Acta Neuropathologica·Kurt A Jellinger, Johannes Attems

❮ Previous
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Citations

May 7, 2015·Der Radiologe·W Reith, R Mühl-Benninghaus
Aug 16, 2016·Journal of Neuropathology and Experimental Neurology·Dagmar H HeppWilma D J van de Berg
Oct 22, 2016·Journal of Alzheimer's Disease : JAD·Yuta YoshinoShu-Ichi Ueno
Dec 17, 2016·Lancet Neurology·Johannes Attems
Jul 15, 2017·Nature Reviews. Neurology·Fanny M Elahi, Bruce L Miller
Oct 28, 2017·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Piotr LewczukUNKNOWN Members of the WFSBP Task Force Working on this Topic: Peter Riederer, Carla Gallo, Dimitrios Kapogiannis, Andrea Lopez Mato
Dec 13, 2017·Environmental Science. Nano·Bo WangFeng Ding
May 16, 2018·Journal of Alzheimer's Disease : JAD·Jennifer RoudilUNKNOWN Brainbank Neuro-CEB Neuropathology Network
May 20, 2018·Neurologia i neurochirurgia polska·Anna PierzchlińskaJarosław Sławek
Dec 26, 2018·Brain Pathology·Lina PattersonChristopher M Morris
Mar 2, 2018·Alzheimer's Research & Therapy·Alan J ThomasJohannes Attems
Mar 8, 2018·BMC Medicine·Kurt A Jellinger, Amos D Korczyn
Jul 5, 2019·Journal of Neuropathology and Experimental Neurology·Lina PattersonChristopher M Morris
Aug 15, 2019·Brain : a Journal of Neurology·Seán O'DowdJohn-Paul Taylor
Dec 10, 2019·Journal of Parkinson's Disease·Allan K HansenPer Borghammer
Aug 6, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Markus MandlerRobert A Rissman
Nov 5, 2017·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Tanis J FermanDennis W Dickson
Oct 30, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·David G CoughlinDavid J Irwin
Dec 2, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Jolien F LeijenaarRik Ossenkoppele
Dec 22, 2019·Neurology·Kejal KantarciMelissa E Murray
Aug 25, 2019·Journal of Neurology, Neurosurgery, and Psychiatry·Callum SmithDonald G Grosset
Sep 7, 2020·Neuropathology and Applied Neurobiology·D G CoughlinD J Irwin
Oct 30, 2016·Journal of Neurology, Neurosurgery, and Psychiatry·A W LemstraS A M Sikkes
Mar 8, 2017·Journal of Neural Transmission·Lauren WalkerJohannes Attems
Nov 19, 2015·Expert Review of Vaccines·Thomas Wisniewski, Eleanor Drummond
Sep 17, 2016·Proteomics·Timothy D Veenstra
May 11, 2017·Acta Neuropathologica·Alifiya KapasiJulie A Schneider
Mar 27, 2018·Journal of Alzheimer's Disease : JAD·Andrea GalbiatiLuigi Ferini-Strambi
May 20, 2018·Molecular Neurodegeneration·Michael C PaceDavid R Borchelt
Dec 15, 2018·Geriatrics & Gerontology International·Masato IshibashiEtsuro Matsubara
Apr 30, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Somin KwonEliezer Masliah
Nov 20, 2016·Annals of Neurology·Kejal KantarciRonald C Petersen
Dec 23, 2016·Molecular Neurobiology·Chiara MontiTiziana Alberio

❮ Previous
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