Neuropathy target esterase (NTE/PNPLA6) and organophosphorus compound-induced delayed neurotoxicity (OPIDN)

Advances in Neurotoxicology
Rudy J RichardsonSanjeeva J Wijeyesakere

Abstract

Systemic inhibition of neuropathy target esterase (NTE) with certain organophosphorus (OP) compounds produces OP compound-induced delayed neurotoxicity (OPIDN), a distal degeneration of axons in the central nervous system (CNS) and peripheral nervous system (PNS), thereby providing a powerful model for studying a spectrum of neurodegenerative diseases. Axonopathies are important medical entities in their own right, but in addition, illnesses once considered primary neuronopathies are now thought to begin with axonal degeneration. These disorders include Alzheimer's disease, Parkinson's disease, and motor neuron diseases such as amyotrophic lateral sclerosis (ALS). Moreover, conditional knockout of NTE in the mouse CNS produces vacuolation and other degenerative changes in large neurons in the hippocampus, thalamus, and cerebellum, along with degeneration and swelling of axons in ascending and descending spinal cord tracts. In humans, NTE mutations cause a variety of neurodegenerative conditions resulting in a range of deficits including spastic paraplegia and blindness. Mutations in the Drosophila NTE orthologue SwissCheese (SWS) produce neurodegeneration characterized by vacuolization that can be partially rescued by expressio...Continue Reading

Citations

Oct 21, 2020·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·A K PannuR Vijayvergiya
Jan 24, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Anja Knoll-GellidaPatrick J Babin
Jul 14, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Elizabeth UndianoAntonio Monroy-Noyola
Jul 22, 2021·ACS Chemical Neuroscience·Leslie E DubranaPatrick J Babin
Nov 6, 2021·Experimental and Therapeutic Medicine·Fangyan HuDingxin Long

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Methods Mentioned

BETA
Knockdown
protein assay
NMR
chemical modification
Assay
RIP
biosensor
biosensors
glycosylation
two-hybrid

Software Mentioned

GraphPad

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