Neuropeptide and neuronal marker studies in vitiligo

The British Journal of Dermatology
M S Al'AbadieD J Gawkrodger

Abstract

Neuropeptide and neuronal marker immunoreactivity was studied in skin biopsies from lesional and marginal areas in 12 patients with vitiligo, and in seven normal controls. The vitiligo was active in seven, static in two, and of unknown activity in three. Antibodies against general neuronal marker PGP 9.5 (PGP 9.5), substance P (SP), calcitonin gene-related peptide (CGRP), vasoactive intestinal polypeptide (VIP), and neuropeptide Y (NPY), were used. The epidermis, dermo-epidermal junction, papillary and reticular dermis, and appendages, were assessed semiquantitatively for reactivity with each antibody. Staining with PGP 9.5 in the upper dermis was assessed quantitatively by image analysis. An increase in reactivity against NPY antibody was seen in five of 10 cases (three with active vitiligo) in the marginal areas, and in three of 12 subjects (all with active vitiligo) in the lesional vitiligo areas. VIP antibody reactivity showed a minimal increase in the marginal and lesional vitiligo areas (in two cases each, both of whom had active vitiligo). SP and CGRP reactivities did not differ from normal. PGP 9.5 staining was minimally increased at the dermo-epidermal junction and lower Malpighian layer in biopsies from marginal areas...Continue Reading

References

Sep 1, 1977·The British Journal of Dermatology·M Koga
May 1, 1992·Journal of the American Academy of Dermatology·N MozzanicaA F Finzi
Jan 1, 1991·International Journal of Dermatology·E M FarberS W Lanigan
Aug 1, 1969·The Journal of Investigative Dermatology·W B Shelley, S Ohman
Sep 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·K Tatemoto
Jul 1, 1952·The Journal of Investigative Dermatology·G A SPENCER, J A TOLMACH

❮ Previous
Next ❯

Citations

May 16, 1998·Experimental Dermatology·R W Lambert, R D Granstein
Feb 13, 2001·Clinical and Experimental Dermatology·F Shaffrali, D Gawkrodger
Jan 13, 2006·Journal of the European Academy of Dermatology and Venereology : JEADV·K OngenaeJ-M Naeyaert
Apr 23, 2008·Pigment Cell & Melanoma Research·Sara StrömbergMats J Olsson
Feb 13, 2010·The Australasian Journal of Dermatology·Do-Young KwonKun Woo Park
Nov 17, 2010·Pediatric Dermatology·Angela SinghSandy Milgraum
Jul 28, 2012·Expert Opinion on Pharmacotherapy·Roberta ColucciSilvia Moretti
May 16, 2013·Journal of Cutaneous Medicine and Surgery·Neel Malhotra, Marlene Dytoc
Oct 29, 2015·Journal of Cutaneous Medicine and Surgery·Huma KhurrumEssam Osman
Jun 10, 2017·Biomarkers in Medicine·Hatice AtaşMustafa Kavutçu
Aug 24, 2019·Cell Proliferation·Sarah E Vidal YuchaDavid L Kaplan
Nov 27, 1998·The Journal of Dermatology·F MahmoudG Morgan
Nov 14, 2001·American Journal of Clinical Dermatology·M D Njoo, W Westerhof
Dec 19, 2012·Dermatologic Therapy·Jana HercogováTorello M Lotti
Feb 28, 2013·The Journal of Dermatology·Naoki OisoIchiro Katayama
Feb 18, 2011·Pigment Cell & Melanoma Research·Nanja van GeelUNKNOWN VETF members
Mar 25, 2019·Journal of Cutaneous Medicine and Surgery·Nicole Relke, Melinda Gooderham
Nov 21, 2018·Dermatologic Therapy·C MaduraB S Chandrashekar
Apr 26, 2001·The Journal of Dermatology·T KawakamiM Mihara
Mar 1, 2005·Drugs·Kresimir Kostovic, Aida Pasic
May 15, 2009·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Hana BakBeom Joon Kim
Apr 21, 2009·Anais Brasileiros De Dermatologia·Lucas S C NogueiraRoberto D Azambuja
Sep 16, 2008·The Journal of Dermatology·Chong Won ChoiMyeung Nam Kim
Oct 22, 2008·International Journal of Dermatology·Kyriaki AroniEfstratios S Patsouris
Apr 18, 2012·International Journal of Immunopathology and Pharmacology·A MiniatiT C Theoharides
Dec 19, 2012·Dermatologic Therapy·Brian W LeeTorello M Lotti
Oct 30, 2001·Autoimmunity·E H KempA P Weetman
Jan 5, 2011·The British Journal of Dermatology·D-Y KimS-K Hann
Oct 25, 2020·Clinical and Experimental Dermatology·M S Al Abadie, D J Gawkrodger
Dec 19, 2020·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Anastasia ShakhbazovaRaja K Sivamani
Mar 20, 2021·Frontiers in Immunology·Erica L Katz, John E Harris
Feb 1, 2019·Annals of Dermatology·Hyung-Jin ParkMin Kyung Shin
Dec 24, 1997·Clinics in Dermatology·I C Le Poole, P K Das
Jun 12, 2021·Experimental Dermatology·Zoya T AndersonMelissa L Harris

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Acta Medica Croatica : C̆asopis Hravatske Akademije Medicinskih Znanosti
E HristakievaJ Shani
Archives of Dermatological Research
Anitta JärvikallioAnita Naukkarinen
© 2021 Meta ULC. All rights reserved