Neuropeptide B mediates female sexual receptivity in medaka fish, acting in a female-specific but reversible manner

ELife
Towako Hiraki-KajiyamaKataaki Okubo

Abstract

Male and female animals display innate sex-specific mating behaviors. In teleost fish, altering the adult sex steroid milieu can effectively reverse sex-typical mating behaviors, suggesting remarkable sexual lability of their brains as adults. In the teleost medaka, neuropeptide B (NPB) is expressed female-specifically in the brain nuclei implicated in mating behavior. Here, we demonstrate that NPB is a direct mediator of estrogen action on female mating behavior, acting in a female-specific but reversible manner. Analysis of regulatory mechanisms revealed that the female-specific expression of NPB is dependent on direct transcriptional activation by estrogen via an estrogen-responsive element and is reversed in response to changes in the adult sex steroid milieu. Behavioral studies of NPB knockouts revealed that female-specific NBP mediates female receptivity to male courtship. The female-specific NPB signaling identified herein is presumably a critical element of the neural circuitry underlying sexual dimorphism and lability of mating behaviors in teleosts.

References

Feb 1, 1975·The Journal of Experimental Zoology·L S DemskiJ W Gerald
Jun 1, 1982·Physiology & Behavior·A L Kyle, R E Peter
Jan 1, 1995·Brain, Behavior and Evolution·R G Northcutt
Nov 25, 1998·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·F L Moore, C A Lowry
Nov 30, 1998·Science·A AmoresJ H Postlethwait
Oct 5, 2001·Nature Reviews. Genetics·N G CopelandD L Court
Jul 16, 2002·The Journal of Biological Chemistry·Ryo FujiiMasahiko Fujino
Oct 29, 2002·The Journal of Biological Chemistry·Stéphane BrezillonMarc Parmentier
Apr 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Hirokazu TanakaMasashi Yanagisawa
Aug 30, 2003·Neuroscience Letters·Siok L DunNae J Dun
Dec 9, 2003·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Susan C TiltonWilliam H Benson
Jul 16, 2004·Archives of Environmental Contamination and Toxicology·Christy M ForanDuane B Huggett
Jun 1, 2006·The Journal of Comparative Neurology·Valerie R JacksonOlivier Civelli
Jun 21, 2006·The Journal of Comparative Neurology·Henning Schneider, Beth Sulner
Oct 4, 2006·Frontiers in Neuroendocrinology·Christine K Wagner
Jan 19, 2007·Brain, Behavior and Evolution·Kengo Funakoshi, Masato Nakano
Jul 11, 2007·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Prisca ChapoutonLaure Bally-Cuif
Apr 28, 2009·General and Comparative Endocrinology·Arimune Munakata, Makito Kobayashi
Jun 24, 2009·Developmental Neuroscience·Elizabeth Adkins-Regan
Dec 15, 2010·The European Journal of Neuroscience·Jacques BalthazartGregory F Ball
Feb 22, 2011·Journal of Neuroendocrinology·K OkuboY Nagahama
Mar 15, 2011·Behavioural Brain Research·Antje Jahn-EimermacherJacob Raber
May 27, 2011·Nature Neuroscience·Margaret M McCarthy, Arthur P Arnold
Jul 30, 2011·The Journal of Comparative Neurology·Lauren A O'Connell, Hans A Hofmann
Feb 7, 2012·Cell·Xiaohong XuNirao M Shah
Oct 19, 2012·Proceedings. Biological Sciences·Towako HirakiKataaki Okubo
Mar 22, 2013·Frontiers in Endocrinology·Takeshi Sakurai
Jun 1, 2013·Hormones and Behavior·James L Goodson, Marcy A Kingsbury
Apr 20, 2014·Neuron·Cindy F Yang, Nirao M Shah
Aug 5, 2014·European Journal of Pharmacology·J G VeeningB Olivier
Sep 10, 2014·Neuroscience and Biobehavioral Reviews·Gregory F BallMargaret M McCarthy
Jul 3, 2015·Frontiers in Neuroscience·Noriya Watanabe, Miyuki Yamamoto
Sep 9, 2015·Frontiers in Behavioral Neuroscience·Margaret M McCarthy, Bridget M Nugent

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Citations

May 30, 2020·Proceedings of the National Academy of Sciences of the United States of America·Kimberly MitchellVance L Trudeau
Nov 22, 2020·Communications Biology·Samuel J TindellAlexey L Arkov
Jul 3, 2021·International Journal of Molecular Sciences·Tatiana WojciechowiczMarek Skrzypski

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Datasets Mentioned

BETA
LC375958

Methods Mentioned

BETA
PCR
transgenic
in vitro transcription
fluorescence
transfection
Assay
Knockout

Software Mentioned

Adobe Photoshop
GraphPad Prism
InterProScan
ImageJ
Ensembl
GraphPad
BLAST
ClustalW
Ensembl genome browser

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