Neuropeptide FF (NPFF) control of magnocellular neurosecretory cells of the rat hypothalamic paraventricular nucleus (PVN)

Peptides
Jack H JhamandasKim H Harris

Abstract

Neuropeptide FF (NPFF) is an octapeptide belonging to an extended family of RF amide peptides that have been implicated in a wide variety of physiological functions in the brain. NPFF and its receptors are abundantly expressed in the rat brain and spinal cord including the hypothalamic paraventricular nucleus (PVN), an autonomic nucleus critical for the secretion of neurohormones and the regulation of sympathetic outflow. In this study, we sought to examine the effects of NPFF on GABAergic inhibitory synaptic input to magnocellular neurosecretory cells (MNCs) of the PVN, which secrete the neurohormones, vasopressin and oxytocin from their terminals in the neurohypophysis. Whole cell patch clamp recordings under voltage clamp conditions were performed from PVN MNCs in the brain slice. Bicuculline-sensitive inhibitory postsynaptic currents (IPSCs) were isolated in the presence of glutamate receptor blockers. In tetrodotoxin, NPFF (5 microM) caused an increase in frequency, but not amplitude of miniature inhibitory postsynaptic currents (mIPSCs) in MNCs indicating a presynaptic locus of action for this peptide. Intracerebroventricular application of NPFF resulted in an activation of GABAergic neurons located adjacent to the PVN as...Continue Reading

References

Jan 1, 1983·Annual Review of Neuroscience·L W Swanson, P E Sawchenko
Jan 1, 1993·Molecular Neurobiology·T L Krukoff
May 21, 1998·European Journal of Pharmacology·M Roumy, J M Zajac
Jun 26, 2001·Trends in Pharmacological Sciences·J M Zajac

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Citations

Mar 2, 2010·Invertebrate Neuroscience : in·Robert J WalkerLindy Holden-Dye
Oct 14, 2009·The European Journal of Neuroscience·Li MaJack H Jhamandas
Dec 2, 2010·The Journal of Comparative Neurology·Valeri D GoncharukDick F Swaab
Aug 28, 2014·Brain and Behavior·Valeri D GoncharukDick F Swaab
Aug 22, 2017·International Journal of Molecular Sciences·Ya-Tin LinJin-Chung Chen
Feb 10, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jack H JhamandasKim H Harris

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