Neuropeptide FF receptors antagonist, RF9, attenuates opioid-evoked hypothermia in mice

Peptides
Yi-qing WangRui Wang

Abstract

The present study used the endpoint of hypothermia to investigate opioid and neuropeptide FF (NPFF) interactions in conscious animals. Both opioid and NPFF systems played important roles in thermoregulation, which suggested a link between opioid receptors and NPFF receptors in the production of hypothermia. Therefore, we designed a study to investigate the relationship between opioid and NPFF in control of thermoregulation in mice. The selective NPFF receptors antagonist RF9 (30nmol) injected into the third ventricle failed to induce significant effect, but it completely antagonized the hypothermia of NPFF (45 nmol) after cerebral administration in mice. In addition, RF9 (30 nmol) co-injected i.c.v. in the third ventricle reduced the hypothermia induced by morphine (5nmol,) or nociceptin/orphanin FQ (N/OFQ) (2 nmol). Neither the classical opioid receptors antagonist naloxone (10 nmol) nor NOP receptor antagonist [Nphe(1)]NC(1-13)NH(2) (7.5 nmol) reduced the hypothermia induced by the central injection of NPFF at dose of 45 nmol. Co-injected with a low dose of NPFF (5 nmol), the hypothermia of morphine (5 nmol) or N/OFQ (2 nmol) was not modified. These results suggest that NPFF receptors activation is required for opioid to prod...Continue Reading

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Citations

Feb 26, 2013·Chemical Reviews·Lukas WankaPeter R Schreiner
Apr 20, 2012·The Journal of Pharmacology and Experimental Therapeutics·Laurence L MillerLinda A Dykstra
Jun 20, 2012·Future Medicinal Chemistry·Jessica V Mankus, Christopher R McCurdy
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Dec 1, 2009·Peptides·Franck TalmontCatherine Mollereau
Nov 26, 2009·Peptides·Alexandre BetourneLionel Mouledous
Oct 2, 2009·Peptides·Richard J Bodnar
Nov 8, 2012·Bioorganic & Medicinal Chemistry Letters·Ronan GealageasFrédéric Bihel
Aug 19, 2021·Scientific Reports·Evans K CheruiyotJennie E Pryce

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