Neuropeptide G Protein-Coupled Receptors as Oncotargets

Frontiers in Endocrinology
Terry W MoodyRobert T Jensen

Abstract

Neuropeptide G protein-coupled receptors (GPCRs) are overexpressed on numerous cancer cells. In a number of tumors, such as small cell lung cancer (SCLC), bombesin (BB) like peptides and neurotensin (NTS) function as autocrine growth factors whereby they are secreted from tumor cells, bind to cell surface receptors and stimulate growth. BB-drug conjugates and BB receptor antagonists inhibit the growth of a number of cancers. Vasoactive intestinal peptide (VIP) increases the secretion rate of BB-like peptide and NTS from SCLC leading to increased proliferation. In contrast, somatostatin (SST) inhibits the secretion of autocrine growth factors from neuroendocrine tumors (NETs) and decreases proliferation. SST analogs such as radiolabeled octreotide can be used to localize tumors, is therapeutic for certain cancer patients and has been approved for four different indications in the diagnosis/treatment of NETs. The review will focus on how BB, NTS, VIP, and SST receptors can facilitate the early detection and treatment of cancer.

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Citations

May 11, 2019·Annals of the New York Academy of Sciences·Terry W Moody
Jul 18, 2019·Expert Review of Respiratory Medicine·Hildegard M Schuller
May 21, 2020·International Journal of Molecular Sciences·Aldona Kasprzak, Agnieszka Adamek
Sep 24, 2020·Journal of Molecular Neuroscience : MN·Terry W MoodyRobert T Jensen
Nov 5, 2019·Frontiers in Genetics·Kyle R RoellAlison A Motsinger-Reif
Nov 17, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Paige M GlumacAaron M LeBeau
May 13, 2019·Trends in Pharmacological Sciences·Paul A InselAmy M Chinn
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·João Franco MachadoTânia S Morais
Jun 27, 2020·Current Medicinal Chemistry·Maximilian KlinglerElisabeth Von Guggenberg

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Datasets Mentioned

BETA
GM6001

Methods Mentioned

BETA
xenografts
biopsy

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