PMID: 7536949Jan 5, 1995Paper

Neuropeptide levels in discrete brain regions in the iminodipropionitrile-induced persistent dyskinesia rat model

Regulatory Peptides
Y KawadaA Mori

Abstract

To clarify the role of neuropeptides in dyskinesia induced by iminodipropionitrile (IDPN), the levels of five representative neuropeptides were examined in discrete regions of the rat brain 4 weeks after intraperitoneal injection of IDPN. The five neuropeptides examined were methionine-enkephalin (Met-Enk), substance P (SP) and somatostatin, which are closely related to extrapyramidal function, and thyrotropin-releasing hormone (TRH) and cholecystokinin octapeptide (CCK-8), which are closely related to the neural mechanism of the dopamine system. IDPN pretreatment significantly increased Met-Enk in the basal ganglia but not SP or somatostatin; however, all three neuropeptide levels were increased in the hindbrain. In IDPN-treated rats, TRH and CCK-8 levels were increased in the nucleus accumbens, and the frontal cortical CCK-8 level was extremely increased. These findings, together with previous reports, suggest that neuropeptides in the basal ganglia, hindbrain and cerebral cortex play important roles in the manifestation of dyskinetic symptoms.

References

Jan 1, 1979·Annual Review of Neuroscience·S H Snyder, S R Childers
Sep 14, 1979·Brain Research·T D ReisineH I Yamamura
Jan 1, 1975·Journal of Neuroscience Research·P J LanglaisS Gabay
Dec 1, 1990·Journal of the Neurological Sciences·M AsanumaA Mori
Apr 1, 1991·Brain Research Bulletin·A S PerumalJ L Cadet
Apr 1, 1987·Pharmacology, Biochemistry, and Behavior·J L CadetW J Freed
Jan 1, 1968·International Journal of Neuropharmacology·J K TewsW E Stone
Dec 1, 1984·Neuropharmacology·A R Green
Jun 1, 1984·Experimental Neurology·J S Schneider
Dec 15, 1957·Experientia·L KALLIOMAKIE KULONEN

❮ Previous
Next ❯

Citations

Jan 1, 1997·Brain Research Bulletin·E TothE S Vizi
Feb 27, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Haseeb Ahmad KhanIbrahim Abdulwahid Arif
Dec 18, 2013·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Khalid Elfakki IbrahimFayza Ahmad Omer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.