Neuropeptide signalling: a repository of targets for novel endectocides?

Trends in Parasitology
Angela MousleyAaron G Maule

Abstract

The only available parasiticides with a spectrum of action that includes a broad range of helminth and arthropod parasites are the macrocyclic lactones. Designated endectocides, these drugs have action against both endoparasitic nematodes and ectoparasitic arthropods. Unfortunately, the discovery of such drugs is exceedingly rare and there is no evidence that novel endectocidal agents will be identified and developed in the short to medium term. However, the discovery of neuropeptides with motor-modulatory activities in both arthropods and helminths, coupled with recent progress in the characterization of invertebrate neuropeptide receptors, has the potential to propel neuropeptide signalling to the forefront of efforts to develop a novel endectocide.

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Citations

Jun 11, 2014·General and Comparative Endocrinology·Andrew E Christie
Apr 14, 2009·International Journal for Parasitology·Paul McVeighAaron G Maule
Mar 10, 2009·Trends in Parasitology·Steven J HussonLiliane Schoofs
Mar 17, 2007·International Journal for Parasitology·Hanan H OmarTim A Day
Jul 11, 2006·Trends in Parasitology·Paul McVeighAaron G Maule
Aug 25, 2005·Veterinary Parasitology·Georg von Samson-Himmelstjerna, William Blackhall
May 22, 2010·Molecular and Biochemical Parasitology·Louise E AtkinsonAaron G Maule
Jan 4, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Michael J KimberAaron G Maule
Sep 28, 2005·International Journal for Parasitology·Angela MousleyNikki J Marks

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