Neuropeptide W: a key player in the homeostatic regulation of feeding and energy metabolism?

Annals of the New York Academy of Sciences
Fumiko TakenoyaSeiji Shioda

Abstract

Neuropeptide W (NPW), recently isolated from porcine hypothalamus, has been identified as the endogenous ligand for both NPBWR1 (GPR7) and NPBWR2 (GPR8), which belong to the orphan G protein-coupled receptor family. NPW is thought to play an important role in the regulation of feeding and drinking behavior, and to be related to the stress response. NPW-containing neurons are localized in several regions of the brain, including the hypothalamus, hippocampus, limbic system, midbrain, and brain stem. Accumulated evidence suggests that hypothalamic neuropeptides, such as neuropeptide Y (NPY), orexin, melanin-concentrating hormone (MCH), and proopiomelanocortin (POMC), are involved in the regulation of feeding behavior and energy homeostasis via neuronal circuits in the hypothalamus. NPW also forms part of the feeding-regulating neuronal circuitry in conjunction with other feeding-regulating peptide-containing neurons within the hypothalamus. We summarize our current understanding of the distribution of NPW and of the neuronal interactions between NPW and the different feeding-regulating peptide-containing neurons. This review also discusses evidence for the dichotomous actions of NPW on energy balance and the potential mechanisms i...Continue Reading

References

Nov 26, 1976·Brain Research·C B SaperW M Cowan
Feb 1, 1997·Endocrinology·J K ElmquistC B Saper
Apr 15, 2000·Nature·M W SchwartzD G Baskin
Jul 16, 2002·The Journal of Biological Chemistry·Ryo FujiiMasahiko Fujino
Jul 20, 2002·The Journal of Biological Chemistry·Yukio ShimomuraMasahiko Fujino
Oct 29, 2002·The Journal of Biological Chemistry·Stéphane BrezillonMarc Parmentier
Apr 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Hirokazu TanakaMasashi Yanagisawa
Aug 20, 2003·Proceedings of the National Academy of Sciences of the United States of America·Makoto IshiiJeffrey M Friedman
Aug 30, 2003·Neuroscience Letters·Siok L DunNae J Dun
Sep 10, 2003·Endocrinology·Muhtashan S MondalMasamitsu Nakazato
Nov 11, 2003·Life Sciences·Dennis K LeeBrian F O'Dowd
Sep 4, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Meghan M TaylorWillis K Samson
Oct 7, 2004·European Journal of Pharmacology·Yan-Ling XuOlivier Civelli
May 12, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Allen S LevineLuis de Lecea
Aug 2, 2005·Trends in Pharmacological Sciences·Janet J Maguire, Anthony P Davenport
Jan 6, 2006·The Journal of Endocrinology·M S MondalM Nakazato
May 16, 2006·Brain Research·Yoji KitamuraTakeshi Sakurai
Oct 3, 2006·Regulatory Peptides·Nanshou YuHiroshi Kannan
Dec 2, 2009·Neuropeptides·Fumiko TakenoyaSeiji Shioda
Mar 2, 2010·Endocrinology·Yukari DateMasamitsu Nakazato

❮ Previous
Next ❯

Citations

Mar 15, 2011·General and Comparative Endocrinology·Shinji NagataHiromichi Nagasawa
Aug 13, 2015·Research in Veterinary Science·Rui FangZhihai Lei
Dec 4, 2010·The FEBS Journal·Kanako ShibaSeiji Shioda
Feb 19, 2015·Journal of Molecular Neuroscience : MN·Fumiko TakenoyaSeiji Shioda
Jan 25, 2011·Journal of Pharmacological Sciences·Shinichi HaradaShogo Tokuyama
Apr 5, 2017·Acta Physiologica·H LiA J Page
Dec 8, 2016·Journal of Physiology and Biochemistry·Teresa GrzelakMarta Tyszkiewicz-Nwafor
Aug 9, 2018·Frontiers in Physiology·Magdalena Chottova Dvorakova
Jul 20, 2016·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Satoshi HirakoSeiji Shioda
Jan 1, 2011·Journal of Pharmacological Sciences·Shinichi HaradaShogo Tokuyama

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Related Papers

Journal of Peptide Science : an Official Publication of the European Peptide Society
Maki KanesakaShigeru Tokita
International Journal of Obesity : Journal of the International Association for the Study of Obesity
S S Hussain, S R Bloom
© 2021 Meta ULC. All rights reserved