Neuropeptide Y and α-MSH circadian levels in two populations with low body weight: anorexia nervosa and constitutional thinness

PloS One
B GaluscaNicolas Chartrel

Abstract

Anorexia nervosa (AN) presents an adaptive appetite regulating profile including high levels of ghrelin and 26RFa (orexigenic) and low levels of leptin and PYY (anorexigenic). However, this adaptive mechanism is not effective in promoting food intake. The NPY/proopiomelanocortin (POMC) system plays a crucial role in the regulation of feeding behavior as NPY is the most potent orexigenic neuropeptide identified so far and as the POMC-derived peptide α-MSH drastically reduces food intake, and this peptidergic system has not been thoroughly studied in AN. The aim of the present study was thus to investigate whether a dysfunction of the NPY/POMC occurs in two populations with low body weight, AN and constitutional thinness (CT). This was a cross-sectional study performed in an endocrinological unit and in an academic laboratory. Three groups of age-matched young women were studied: 23 with AN (AN), 22 CT and 14 normal weight controls. Twelve-point circadian profiles of plasma NPY and α-MSH levels were measured in the three groups of investigated subjects. No significant circadian variation of NPY was detected between the three groups. Plasma α-MSH levels were significantly lower in AN (vs controls) all over the day. The CT group, c...Continue Reading

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Citations

Apr 3, 2016·The International Journal of Eating Disorders·Jonathan BretonSergueï O Fetissov
May 29, 2018·Hormone Molecular Biology and Clinical Investigation·Odile ViltartVirginie Tolle
Jun 2, 2020·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Mélina BaillyJulien Verney
Apr 24, 2020·The British Journal of Nutrition·Mélina BaillyJulien Verney
Feb 14, 2019·Translational Psychiatry·Nicolas LucasSergueï O Fetissov
Sep 13, 2019·The International Journal of Eating Disorders·Christopher HübelGerome Breen
Mar 14, 2019·Frontiers in Neuroscience·Jovana JoksimovicGvozden Rosic
Jun 3, 2020·Journal of Sleep Research·Nada AhmedBrian B Koo
Feb 7, 2020·Eating and Weight Disorders : EWD·Yanran HuJue Chen
Mar 28, 2021·European Journal of Clinical Nutrition·Mélina BaillyJulien Verney
May 1, 2021·Reviews in Endocrine & Metabolic Disorders·Mélina BaillyJulien Verney

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Methods Mentioned

BETA
x-ray
ELISA

Software Mentioned

StatView
MONICA

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