Neuropeptide Y and galanin binding sites in rat and monkey lumbar dorsal root ganglia and spinal cord and effect of peripheral axotomy

The European Journal of Neuroscience
X ZhangT Hökfelt

Abstract

Using monoiodinated peptide YY (PYY) and galanin as radioligands, and neuropeptide Y (NPY) fragments, the distribution of NPY binding sites and its subtypes Y1 and Y2, and of galanin binding sites, was investigated in rat and monkey lumbar (L) 4 and L5 dorsal root ganglia (DRG) and spinal cord before and after a unilateral sciatic nerve cut, ligation or crush. Receptor autoradiography revealed that [125I]PYY bound to some DRG neurons and a few nerve fibres in normal rat DRG, and most of these neurons were small. NPY binding sites were observed in laminae I-IV and X of the rat dorsal horn and in the lateral spinal nucleus, with the highest density in laminae I-II. [125I]PYY binding was most strongly attenuated by NPY13-36, a Y2 agonist, and partially inhibited by [Leu31,Pro34]NPY, a Y1 agonist, in both rat DRG and the dorsal horn of the spinal cord. These findings suggest that Y2 receptors are the main NPY receptors in rat DRG and dorsal horn, but also that Y1 receptors exist. After sciatic nerve cut, PYY binding markedly increased in nerve fibres and neurons in DRG, especially in large neuron profiles, and in laminae III-IV of the dorsal horn, as well as in nerve fibres in dorsal roots and the sciatic nerve. Incubation with NPY...Continue Reading

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Citations

Mar 1, 2002·Experimental Neurology·Pablo R BrumovskyTomas Hökfelt
Nov 8, 2001·European Journal of Pharmacology·Z Wiesenfeld-Hallin, X J Xu
Jul 4, 1998·Brain Research. Brain Research Reviews·T HökfeltJ H Walsh
Mar 20, 2002·Neuroscience Research·Hironobu SuzukiTakeyasu Maeda
Jun 1, 1997·Brain Research. Molecular Brain Research·E L GustafsonT A Branchek
May 5, 1999·Journal of Anatomy·G Terenghi
Dec 1, 1995·The European Journal of Neuroscience·R R JiT Hökfelt
Feb 3, 1999·Annals of the New York Academy of Sciences·Z Wiesenfeld-Hallin, X J Xu
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·Z Q XuT Hökfelt
Aug 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·H X LiuT Hökfelt
Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·X ZhangT Hökfelt
Feb 9, 2012·Pain Research and Treatment·Richard P HulseDavid Wynick
Jan 16, 2007·Trends in Pharmacological Sciences·Pablo BrumovskyTomas Hökfelt
Jan 20, 2007·Peptides·Tomas HökfeltMarcelo Villar
Sep 11, 2003·The Journal of Comparative Neurology·Françoise MennickenDajan O'Donnell
Dec 11, 2007·The Journal of Comparative Neurology·Yongling LiAnnica Dahlström
Jul 19, 2005·The Journal of Comparative Neurology·Pablo BrumovskyTomas Hökfelt
Nov 12, 2003·The Journal of Pharmacology and Experimental Therapeutics·Xiao-Ying HuaTony L Yaksh
Jun 16, 1999·Journal of Neurophysiology·M C JiangG F Gebhart

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