Neuropeptide Y and pancreatic polypeptide: effects on thyroid hormone secretion in the mouse

European Journal of Pharmacology
B Ahrén

Abstract

Neuropeptide Y (NPY) is known to occur in adrenergic nerves within the thyroid gland and may thus be released concomitantly with noradrenaline upon adrenergic activation. In this study, the effects of combined administration of NPY and noradrenaline on thyroid hormone secretion were investigated under in vivo conditions in the mouse. Mice were pretreated with radioiodine and thyroxine: the subsequent release of radioiodine into blood upon stimulation is a reflection of the release of thyroid hormones since more than 90% of the released radioiodine is in the form of thyroid hormones. It was found that TSH enhanced the radioiodine levels in blood to 197 +/- 8% (P less than 0.01). Noradrenaline inhibited the TSH-induced thyroid hormone secretion to 168 +/- 6% (P less than 0.01), and NPY potentiated this inhibitory action of noradrenaline (P less than 0.01): the TSH-induced thyroid hormone secretion was only 19 +/- 6% after administration of both noradrenaline and NPY. Furthermore, alpha-adrenoceptor blockade by phentolamine abolished the effect of noradrenaline on TSH-induced thyroid hormone secretion and, during alpha-adrenoceptor blockade, NPY potentiated the secretory response to TSH. To study the specificity of the effects exe...Continue Reading

References

Jan 16, 1974·Life Sciences·A MelanderF Sundler
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Oct 1, 1965·Acta Endocrinologica·C Rerup, A Melander
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Sep 1, 1958·Endocrinology·J M McKENZIE

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Citations

Jan 1, 1988·Pharmacology & Therapeutics·E K Potter
Dec 10, 1993·Regulatory Peptides·J D White
Jul 13, 2002·The Journal of Comparative Neurology·Hideki MatsudaTomas Hökfelt
Feb 5, 2009·The Journal of Clinical Endocrinology and Metabolism·Petra KokHanno Pijl
Dec 1, 1988·International Journal of Peptide and Protein Research·W DanhoE T Kaiser
Aug 19, 2006·The Journal of Experimental Biology·Vesna RajkovicOlle Johansson

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