PMID: 9533641Apr 9, 1998Paper

Neuropeptide Y and somatostatin in the anterior piriform cortex alter intake of amino acid-deficient diets

Peptides
S L CummingsD W Gietzen

Abstract

Neuropeptides affect food intake via peripheral and brainstem mechanisms, but their roles in mediating feeding via the cerebral cortex have received little attention. The anterior piriform cortex (APC) appears to play a critical role in neuroperception of deficiencies of essential amino acids (AA) and the anorectic response to such deficiencies. The neural circuitry underlying the role of this paleocortex in these events is not understood. We have shown that neurons containing neuropeptide Y (NPY) and somatostatin (SOM) are cytoarchitecturally in positions to relate synaptically to the neurons of the APC which may mediate responses to AA. Thus, we hypothesized that NPY and SOM administered intracortically to the APC would directly affect food intake in a threonine-imbalanced model. We determined that NPY at 1-1.5 nmol decreased intake of the AA-deficient diet for 3 h, with a cumulative effect that extended through 6 h. SOM had a dual effect; at 1 pmol it increased intake of the AA-deficient diet for 3 h; at 2 nmol, SOM decreased intake of the AA-deficient diet for over 9 h, with a cumulative effect that persisted through 12 h. In the first 3 h, intake of animals receiving 1 pmol of SOM differed significantly from those receivin...Continue Reading

References

Apr 15, 1978·The Journal of Comparative Neurology·L B Haberly, J L Price
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·S P KalraP S Kalra
Dec 10, 1990·Brain Research·D Feifel, F J Vaccarino
Sep 1, 1989·Physiology & Behavior·D W GietzenQ R Rogers
Sep 1, 1973·Journal of Comparative and Physiological Psychology·J GibbsG P Smith
Jul 1, 1970·Physiological Reviews·A E HarperR M Wohlhueter
Jan 15, 1969·Life Sciences·P M Leung, Q R Rogers
Sep 1, 1971·The American Journal of Physiology·P M Leung, Q R Rogers
Aug 13, 1984·Life Sciences·G AponteT Yamada
Oct 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·S H HendryP C Emson
Jan 1, 1984·Regulatory Peptides·J M AllenS R Bloom
Nov 1, 1984·Peptides·A S Levine, J E Morley
May 1, 1993·Molecular and Chemical Neuropathology·J HamM F Scanlon
Jan 1, 1994·Pharmacology, Biochemistry, and Behavior·J C Jiang, D W Gietzen
Apr 1, 1993·The Journal of Nutrition·D W Gietzen
May 1, 1993·Physiology & Behavior·J L BeverlyQ R Rogers

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Citations

Jun 1, 2015·Hormones and Behavior·Andreas StengelYvette Taché
Dec 18, 2001·Brain Research·Ban G TruongDorothy W Gietzen
May 31, 2007·The Journal of Comparative Neurology·Federica BruzzoneNicolas Chartrel
Jan 1, 1999·Nutritional Neuroscience·J E BlevinsD W Gietzen
Mar 16, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·S ChamorroN Levens
Apr 11, 2020·International Journal of Molecular Sciences·Ujendra Kumar, Sneha Singh
Jun 27, 2019·Annals of the New York Academy of Sciences·Andreas Stengel, Yvette Taché
May 9, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Giuseppe Scalera

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