Abstract
It has been shown recently that low doses of sigma (sigma) receptor ligands like 1,3-di-(2-tolyl)guanidine (DTG), (+)N-allylnormetazocine [(+)SKF 10,047] and (+)pentazocine can antagonize learning impairments induced by dizocilpine (MK-801), a non-competitive antagonist at the NMDA receptor channel. This antagonism has been proposed to involve sigma receptor sites since it is blocked by the administration of purported sigma antagonists such as NE-100 and BMY-14802. It has also been demonstrated that peptides of the neuropeptide Y (NPY) and calcitonin gene-related peptide (CGRP) families modulate, in vivo, sigma labelling and electrophysiological effects in the hippocampal formation. Accordingly, we investigated if NPY- and CGRP-related peptides modulate cognitive processes by interacting with sigma sites in mice. In order to test this hypothesis, a step-down passive avoidance task was used. Interestingly, similarly to various sigma agonists, NPY, peptide YY (PYY) and the Y1 agonist [Leu31Pro34]NPY (but not NPY[13-36], a purported Y2 agonist), as well as hCGRPalpha and the purported CGRP2 agonist [Cys(ACM)2-7]hCGRPalpha (but not CGRP[8-37], a CGRP1 receptor antagonist), significantly attenuated learning impairments induced by MK...Continue Reading
References
Mar 1, 1992·Trends in Pharmacological Sciences·R QuirionD P Taylor
Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·H HerzogL A Selbie
Jan 1, 1992·Pharmacology & Therapeutics·D R Poyner
Sep 1, 1992·Neuropeptides·A Kovács, G Telegdy
Jul 1, 1992·Pharmacology, Biochemistry, and Behavior·G ClementiF Drago
Jun 30, 1992·Annals of the New York Academy of Sciences·F B JolicoeurS St-Pierre
Jan 25, 1991·European Journal of Pharmacology·S W Tam, K N Mitchell
Nov 1, 1991·Peptides·S F Leibowitz, J T Alexander
Apr 19, 1991·Brain Research·B EarleyJ L Junien
Dec 1, 1990·Neuropharmacology·J Parada-Turska, W A Turski
Sep 17, 1990·Brain Research·S B Hellewell, W D Bowen
Oct 1, 1990·Neuropeptides·S Candeletti, S Ferri
Jan 26, 1988·Brain Research·C L CarpenterD A Greenberg
Apr 25, 1989·European Journal of Pharmacology·W D BowenK A McGarry
Sep 1, 1989·Peptides·J F Flood, J E Morley
Nov 22, 1988·European Journal of Pharmacology·M HeiligE Widerlöv
Oct 18, 1988·European Journal of Pharmacology·B L LargentS H Snyder
Aug 17, 1987·Regulatory Peptides·A PecileP C Braga
Sep 1, 1984·Peptides·D D KrahnJ E Morley
Oct 14, 1994·Brain Research. Developmental Brain Research·J B Hutchins
Dec 1, 1994·Pharmacology, Biochemistry, and Behavior·T MauriceA Privat
Aug 1, 1994·Brain Research·E A Van der Zee, P G Luiten
Aug 11, 1994·European Journal of Pharmacology·K MatsunoS Mita
May 30, 1994·Brain Research·T MauriceT Nabeshima
Oct 5, 1993·European Journal of Pharmacology·F J RomanJ L Junien
Jul 23, 1993·Brain Research·D van RossumR Quirion
Sep 1, 1995·The European Journal of Neuroscience·P BouchardR Quirion
Sep 1, 1995·Physiology & Behavior·A Kovács, G Telegdy
Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·M HannerH Glossmann
Citations
Jul 22, 2004·Behavioural Brain Research·Cristina C CarvajalRémi Quirion
Nov 13, 2013·Neuropeptides·M J Zaben, W P Gray
Nov 12, 2013·Neuropeptides·Eva BorbélyZsuzsanna Helyes
Feb 13, 2001·Brain Research·K MigitaS M Waters
Jun 23, 2000·Behavioural Brain Research·M FioreL Aloe
May 26, 1999·Behavioural Brain Research·M FioreL Aloe
Nov 11, 1999·Neuroscience Letters·L Bracci-LaudieroC Stenfors
Feb 24, 2001·Journal of Chemical Neuroanatomy·K KitaichiR Quirion
Apr 12, 2002·Neurotoxicology and Teratology·Marco FioreLuigi Aloe
May 25, 2002·The European Journal of Neuroscience·Vân-Ly PhanTangui Maurice
Dec 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Shang-Yi TsaiTsung-Ping Su
Sep 18, 2002·Gut·V TheodorouL Bueno
Jul 20, 2013·Nutrition Reviews·Bernard Beck, Grégory Pourié
Mar 1, 2011·Neuroscience Letters·Xiao-Dong LiuLong-Chuan Yu
Apr 12, 2008·Molecular and Cellular Endocrinology·William P Gray
Jul 17, 2015·Journal of Neurochemistry·Xin WuFang Wang
Apr 1, 2011·The Journal of Comparative Neurology·Davor StanićTomas Hökfelt
May 12, 2004·Epilepsy Research·Weiwei YenJaideep Kapur
Sep 2, 2006·Pharmacology, Biochemistry, and Behavior·Tangui MauriceJulie Espallergues
Dec 11, 1999·Japanese Journal of Pharmacology·T MauriceT Nabeshima
Feb 16, 2013·Neuropeptides·Christelle Veyrat-DurebexPierrette Gaudreau
Nov 6, 1998·Stroke; a Journal of Cerebral Circulation·A BhardwajJ R Kirsch
Sep 26, 2006·The Journal of Comparative Neurology·Davor StanićTomas Hökfelt
Apr 20, 2005·Journal of Neurochemistry·Owain W HowellWilliam P Gray
Jul 23, 2019·Journal of Psychopharmacology·Johannes Kornhuber, Iulia Zoicas
Jul 30, 2017·Scientific Reports·Johannes Kornhuber, Iulia Zoicas
Aug 14, 2020·Journal of Clinical Medicine·Juho AutioKarl-Heinz Herzig
Jul 16, 2003·The European Journal of Neuroscience·Alexandra TschenettGünther Sperk
Mar 28, 2021·Scientific Reports·Narumi Hashikawa-HobaraNaoya Hashikawa