Neuropeptide Y and truncated neuropeptide Y analogs evoke histamine release from rat peritoneal mast cells. A direct effect on G proteins?

European Journal of Pharmacology
L GrundemarR Håkanson

Abstract

Several regulatory peptides, including neuropeptide Y, can release histamine from mast cells. In the present study we investigated which parts of the neuropeptide Y molecule are required to evoke the release of histamine from isolated rat peritoneal mast cells. In addition, we examined whether the histamine release evoked by neuropeptide Y (and by compound 48/80) is sensitive to the G protein inhibitors pertussis toxin and benzalkonium chloride. Neuropeptide Y released histamine in a concentration-dependent manner. Also a neuropeptide Y analog with the center part substituted by 8-aminooctanoic acid, [Aoc2-27]neuropeptide Y, and the cyclic form of the C-terminal hexapeptide, cyclic neuropeptide Y-(31-36), released histamine. The three peptides were equally effective and equally potent. Neuropeptide Y-(1-24)NH2 also released histamine, but its efficacy was low. The rank order of potency of the analogs tested did not agree with that of any of the previously known or postulated neuropeptide Y receptors. Pretreatment of mast cells with pertussis toxin or benzalkonium chloride markedly inhibited the histamine release evoked by neuropeptide Y, [Aoc2-27]neuropeptide Y and compound 48/80. In conclusion, most of the histamine-releasing ...Continue Reading

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Citations

Mar 15, 1995·European Journal of Pharmacology·M MousliY Landry
Jun 18, 1998·Annals of the New York Academy of Sciences·T C TheoharidesG R Sant
Nov 18, 2008·Neuropharmacology·Elin SandEva Ekblad
Jun 29, 2004·Pulmonary Pharmacology & Therapeutics·David A GronebergAxel Fischer
Jun 30, 2006·The Journal of Pharmacology and Experimental Therapeutics·Iain R ToughHelen M Cox
Jul 20, 2002·The Journal of Pharmacology and Experimental Therapeutics·Grant R StentonA Dean Befus
Apr 25, 2003·Canadian Journal of Physiology and Pharmacology·Zofia ZukowskaLijun Li

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