PMID: 3755528Mar 1, 1986Paper

Neuropeptide Y depresses reflex urinary bladder contractions in rats and modifies central activity of opioid agonists

Peptides
A DrayW Wire

Abstract

The 36 amino acid peptide neuropeptide Y (NPY) has been found distributed in central structures associated with nociception and the actions of opioid analgesics. We therefore studied its central actions on reflex bladder contractions which we have shown to be inhibited by supraspinal and spinal opioid administrations in urethane anesthetized rats. Neuropeptide Y produced a dose related (0.5-2 micrograms per rat) inhibition of bladder contractions following intracerebroventricular (ICV) and spinal intrathecal (IT) administrations. These effects could not be antagonized by naloxone (2 micrograms, ICV or IT) or by ICI 174,864 [N,N-diallyl-Tyr-Aib-Aib-Phe-Leu-OH: Aib = alpha-aminoisobutyric acid] (3 micrograms, ICV or IT). NPY (0.5-1 micrograms) reduced the ICV and IT effects of morphine but potentiated the action of the selective delta-receptor ligand [2-D-penicillamine, 5-L-penicillamine] enkephalin (DPLPE). The effect of the mu-selective opioid ligand [D-Ala2, Me-Phe4, Gly(ol)5] enkephalin (DAGO) were unaffected as were the submaximal ICV and IT actions of noradrenaline. It was concluded that NPY-induced inhibition of bladder activity was not due to a direct opioid receptor interaction. However since NPY consistently changed the...Continue Reading

References

Sep 1, 1984·British Journal of Pharmacology·A D CorbettL E Robson
Sep 3, 1984·European Journal of Pharmacology·A Dray, R Metsch
Aug 26, 1983·Science·Y S AllenJ M Polak
Apr 9, 1981·European Journal of Pharmacology·B K HandaC F Smith
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·H I MosbergT F Burks
Dec 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·E WeberC J Evans
Jan 27, 1984·European Journal of Pharmacology·R CottonD Timms
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·R D'Amato, J W Holaday
Dec 8, 1983·Nature·T E AdrianJ M Polak
Oct 1, 1984·British Journal of Pharmacology·L EdvinssonC Wahlestedt
Dec 23, 1983·Neuroscience Letters·L EdvinssonR Uddman
Sep 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·K Tatemoto
Jan 1, 1982·Annual Review of Physiology·K Docherty, D F Steiner

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Citations

Nov 1, 1987·Peptides·G A OlsonA J Kastin
Jan 1, 1989·Progress in Neuro-psychopharmacology & Biological Psychiatry·C WahlestedtE Widerlöv
Jan 1, 1990·Fundamental & Clinical Pharmacology·J M DangerH Vaudry
Dec 1, 1996·The Journal of Urology·R CroweG Burnstock

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