PMID: 11929194Apr 4, 2002Paper

Neuropeptide Y fails to normalize food intake in zinc-deficient rats

Nutritional Neuroscience
Patricia S WilliamsonR S MacDonald

Abstract

Zinc deprivation results in decreased and cyclic food intake in rats. We determined the response of zinc-deprived rats to neuropeptide Y (NPY). In a preliminary experiment, rats were fed a low (-Zn; <1 mg/kg) or adequate zinc diet (+Zn; 100 mg/kg) for 4 days. NPY (5 or 10 microg) was then administered via an intracerebroventricular (ICV) cannula and food intake measured for 4 h. NPY stimulated food intake in all rats, but the difference in food intake due to zinc deprivation persisted. In a subsequent experiment, rats were fed the low zinc and adequate zinc diets for 4, 5 or 6 days. Food intake was suppressed in rats fed the low zinc compared to the adequate zinc diet on all of these days. When NPY (10 microg) was administered at the onset of the light cycle, the food intake was approximately 2.5-fold greater regardless of dietary zinc status, but the amount of food consumed by rats fed low zinc was approximately one-half the quantity consumed by NPY-stimulated zinc-adequate rats. NPY administered at the onset of dark failed to stimulate food intake in either dietary group although the total intake difference due to zinc status persisted. ICV administration of 5 nmol of zinc prior to NPY injection failed to correct the food int...Continue Reading

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Citations

Apr 22, 2008·Biological Trace Element Research·Ming-Yan JingJian-Feng Wang
Mar 6, 2008·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Jiakui LiZhe Wang
Dec 6, 2003·Science's STKE : Signal Transduction Knowledge Environment·Yo Otsu, Timothy H Murphy
May 27, 2005·Nature·Xuelin LouRalf Schneggenburger
Apr 17, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ferenc Deak, William E Sonntag
Aug 16, 2012·Human Molecular Genetics·Peter L Oliver, Kay E Davies

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