Neuropeptide Y gene expression around meal time in the Brazilian flounder Paralichthys orbignyanus

Journal of Biosciences
Vinicius F CamposTiago Collares

Abstract

Neuropeptide Y (NPY) is considered the major stimulant for food intake in mammals and fish. Previous results indicate that NPY is involved in the feeding behaviour of the Brazilian flounder, Paralichthys orbignyanus. In this study, we evaluated hypothalamic NPY expression before (-2 h), during (0 h) and after feeding (+2 h) in two independent experiments: (1) during a normal feeding schedule and (2) in fish fasted for 2 weeks. During normal feeding, changes in the levels of NPY mRNA were periprandial, with expression levels being significantly elevated at meal time (P less than 0.05) and significantly reduced 2 h later (P less than 0.05). Comparing the fasting and unfasted groups, NPY mRNA levels were significantly higher (P less than 0.05) at -2 h and +2 h in the fasting group, but there was no difference at 0 h. In addition, the higher NPY mRNA levels that were observed in the fasting group were maintained throughout the sampling period. In summary, our results show that NPY expression was associated with meal time (0 h) in food intake regulation.

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Citations

Jul 1, 2015·Molecular and Cellular Endocrinology·Jin-Hyoung KimRobert H Devlin
Apr 17, 2013·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Minh Van NguyenI Rønnestad
May 2, 2017·Frontiers in Endocrinology·I RønnestadH Volkoff
Mar 16, 2019·Frontiers in Endocrinology·Juan Ignacio BertucciS Unniappan
May 30, 2019·Fish Physiology and Biochemistry·Liyuan LvShan He

Related Concepts

Metazoa
Ingestion
Fasting
Halibut
Organum Vasculosum Laminae Terminalis
Neuropeptide Y Like Immunoreactive Peptide
Poly(A) Tail
Gene Expression
Eating
Neuropeptide Y

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