PMID: 3755790Sep 29, 1986Paper

Neuropeptide Y in the intermediate lobe of the frog pituitary acts as an alpha-MSH-release inhibiting factor

Life Sciences
J M DangerH Vaudry

Abstract

The presence of neuropeptide tyrosine (NPY) in the intermediate lobe of the frog pituitary was demonstrated using indirect immunofluorescence, the immunogold technique and a specific radioimmunoassay combined with high pressure liquid chromatography (HPLC). A high density of NPY-containing fibers, was found among the parenchymal cells of the intermediate lobe. These fibers originated from the ventral infundibular nucleus, travelled via the median eminence to the pars intermedia. At the electron microscopic level, NPY-like material was found exclusively in nerve fibers where the product of the immunoreaction was associated to dense-core vesicles. High concentrations of NPY-like peptide were found in neurointermediate lobe extracts. After Sephadex G-50 gel filtration the major peak of immunoreactive material appeared to co-elute with synthetic porcine NPY. Conversely, HPLC analysis revealed that the NPY-like peptide of the frog pituitary had a retention time shorter than the porcine NPY. The localization of NPY-like material in the pars intermedia suggested a possible role of NPY in the regulation of melanotropic cell secretion. In fact, graded concentrations of synthetic NPY induced a dose-dependent inhibition of alpha-melanotro...Continue Reading

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Citations

Mar 10, 2001·The Anatomical Record·F J Rodríguez-GómezJ A Muñoz-Cueto
Jun 1, 1989·Fish Physiology and Biochemistry·J N Fryer
Jan 1, 1988·Pharmacology & Therapeutics·E K Potter
Mar 1, 1995·Pharmacology & Therapeutics·J G WettsteinJ L Junien
Jan 1, 1987·Peptides·B M Verburg-van KemenadeS Saint-Pierre
Nov 8, 2002·Journal of Neuroendocrinology·B G JenksG J M Martens
May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·N ChartrelH Vaudry
Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·A MorP Nicolas
Jan 1, 1990·Fundamental & Clinical Pharmacology·J M DangerH Vaudry
Jan 1, 1990·Annals of the New York Academy of Sciences·R QuirionA Fournier
Jan 1, 1990·Annals of the New York Academy of Sciences·J M DangerH Vaudry
May 31, 1993·Annals of the New York Academy of Sciences·M C TononH Vaudry
Mar 29, 2007·Neuroendocrinology·Bruce G JenksEric W Roubos
Dec 5, 2013·Biological Reviews of the Cambridge Philosophical Society·Iain S HaslamRalf Paus
Jun 1, 1991·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·M LamaczH Vaudry
Jun 13, 2013·Peptides·Shunsuke ShimizuKouhei Matsuda
May 19, 2000·Annals of the New York Academy of Sciences·H VaudryM C Tonon
Jul 24, 2003·American Journal of Physiology. Endocrinology and Metabolism·Rafael Vazquez-MartinezMaria M Malagon
May 31, 1993·Annals of the New York Academy of Sciences·C BlasquezH Vaudry

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