Neuropeptide Y injection into the fourth cerebroventricle stimulates c-Fos expression in the paraventricular nucleus and other nuclei in the forebrain: effect of food consumption

Brain Research
B XuS P Kalra

Abstract

Injection of neuropeptide Y (NPY) into the cerebroventricular system of the rat results in a robust feeding response. In this study, we observed that NPY injection into the fourth ventricle augmented feeding and Fos-like immunoreactivity (FLI) in the paraventricular nucleus (PVN) and in other neighboring nuclei in the forebrain previously implicated in stimulation of feeding. Since the rostral transport of NPY in cerebrospinal fluid after injection into the fourth ventricle is unlikely and the topography of FLI as well as feeding behavior seen in this study are similar to those observed previously after NPY injection into the lateral cerebroventricle, these findings are in accord with the view that feeding induced by NPY injection into the fourth ventricle may also be mediated by NPY receptive elements in the forebrain.

References

Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·S P KalraP S Kalra
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Citations

Apr 6, 2004·Brain Research·Juli E JonesGeorge N Wade
Jun 24, 2003·Physiology & Behavior·Michael G RossMarie H Beall
Aug 1, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·B Beck
Nov 9, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·John-Paul BairdCarrie E Mahoney
Mar 1, 2005·The Psychiatric Clinics of North America·Karine Proulx, Randy J Seeley
Jan 7, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·P Barone
Jun 13, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ai-Jun LiSue Ritter
Mar 15, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·E S CorpG N Wade

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