Neuropeptide Y input to the rat basolateral amygdala complex and modulation by conditioned fear

The Journal of Comparative Neurology
Randy J LeitermannJanice H Urban

Abstract

Within the basolateral amygdaloid complex (BLA), neuropeptide Y (NPY) buffers against protracted anxiety and fear. Although the importance of NPY's actions in the BLA is well documented, little is known about the source(s) of NPY fibers to this region. The current studies identified sources of NPY projections to the BLA by using a combination of anatomical and neurochemical approaches. NPY innervation of the BLA was assessed in rats by examining the degree of NPY coexpression within interneurons or catecholaminergic fibers with somatostatin and tyrosine hydroxylase (TH) or dopamine β-hydroxylase (DβH), respectively. Numerous NPY(+) /somatostatin(+) and NPY(+) /somatostatin(-) fibers were observed, suggesting at least two populations of NPY fibers within the BLA. No colocalization was noted between NPY and TH or DβH immunoreactivities. Additionally, Fluorogold (FG) retrograde tracing with immunohistochemistry was used to identify the precise origin of NPY projections to the BLA. FG(+) /NPY(+) cells were identified within the amygdalostriatal transition area (AStr) and stria terminalis and scattered throughout the bed nucleus of the stria terminalis. The subpopulation of NPY neurons in the AStr also coexpressed somatostatin. Subj...Continue Reading

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Citations

Oct 21, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rinki SahaGal Richter-Levin
Apr 21, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Erin N BobeckLakshmi A Devi
Feb 23, 2021·The Journal of Comparative Neurology·Sawa HorieKazunori Toida
Sep 22, 2021·Stress : the International Journal on the Biology of Stress·Mariana A CortesLynn E Dobrunz

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