PMID: 11922898Mar 30, 2002Paper

Neuropeptide Y modifies the hypertrophic response of adult ventricular cardiomyocytes to norepinephrine

Cardiovascular Research
Marat KanevskijKlaus-Dieter Schlüter

Abstract

The hypertrophic response of adult rat cardiomyocytes to norepinephrine via alpha-adrenoceptor stimulation is limited by an inhibitory cross-talk of simultaneously beta-adrenoceptor stimulation. On the other hand, neuropeptide Y (NPY), known to be co-secreted with norepinephrine from intramural nerve endings of the heart, exerts an anti-beta-adrenergic effect. Therefore, it should be expected that NPY enhances the hypertrophic response to norepinephrine. This hypothesis was addressed in the present study. Isolated adult ventricular cardiomyocytes from rats were used. As parameters of hypertrophic growth we investigated cell volume, cross-sectional area, protein mass. Protein and RNA synthesis were determined by incorporation of [(14)C]phenylalanine or [(14)C]uridine, respectively. Norepinephrine (1 micromol/l) did not significantly increase protein or RNA synthesis. In co-presence of NPY (100 nmol/l), however, norepinephrine increased protein synthesis by 44% and RNA synthesis by 18%. Under the same conditions, NPY enhanced the effect of norepinephrine on cell volume from +6.4 to +18.2%, its effect on cross-sectional area from +16 to +23%, and increased the protein/DNA ratio from 32.5 to 35.6 mg/mg. In parallel, norepinephrine ...Continue Reading

Citations

Mar 21, 2003·Biochemical and Biophysical Research Communications·Jude A ObenAnna Mae Diehl
Oct 5, 2010·Cardiovascular Research·Söhnke HinrichsKlaus-Dieter Schlüter
Jan 19, 2016·Biochimica Et Biophysica Acta·Mauro FranzosoMarco Mongillo
Feb 28, 2017·The Journal of Physiology·Tania Zaglia, Marco Mongillo
Sep 24, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Jude A Oben, Anna Mae Diehl
Jun 21, 2003·Journal of Hypertension·Carmine ZoccaliLorenzo S Malatino
Jul 25, 2019·Progress in Biophysics and Molecular Biology·Anna Di BonaTania Zaglia
Nov 2, 2021·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Carmine ZoccaliUNKNOWN CONNECT Action (Cognitive Decline in Nephro-Neurology European Cooperative Target)

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