Neuropeptide Y (NPY) induced inhibition of preganglionic nerve stimulation evoked release of adrenalin and noradrenaline in the pithed rat

Acta Physiologica Scandinavica
P DahlöfC Dahlöf


NPY, a peptide with 36 amino acid residues, is co-stored together with noradrenaline (NA) in cardiac and sympathetic perivascular nerves as well as with adrenalin (A) in adrenal chromaffin cells. NPY is released together with NA from sympathetic nerves and with A from the adrenal glands and appears to be involved in the control of sympathetic neurotransmission. The aim of the present study was to analyse the effect of NPY on the preganglionic nerve stimulation (PNS) evoked increases in plasma A and NA concentrations in pithed rats. In the first part of the study (I) only one PSN period (2 Hz for 45 s) was performed in each rat and the control group was compared to the NPY treated group. In the second part of the study (II) two PNS periods (1 Hz for 45 s) were performed in each rat, which either received saline or NPY before the second PNS. Thus, interindividual changes between the responses to the first and second PNS in control and NPY rats could be compared. In both study I and II, systemic infusion of NPY (2 micrograms kg-1 min-1 i.v.) significantly reduced the PNS-induced increase in plasma A by 26% and 42%, respectively (P less than 0.05). However, the increase in plasma NA elicited by PNS was significantly reduced only in...Continue Reading


Feb 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·J M LundbergE Theodorsson-Norheim
Jul 1, 1985·Acta Physiologica Scandinavica·A Franco-CerecedaC Dahlöf
Sep 1, 1985·Acta Physiologica Scandinavica·G FriedE Theodorsson-Norheim
Sep 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·K Tatemoto

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