Neuropeptide Y receptor genes on human chromosome 4q31-q32 map to conserved linkage groups on mouse chromosomes 3 and 8

Genomics
C M LutzD A Thompson

Abstract

Npy1r and Npy2r, the genes encoding mouse type 1 and type 2 neuropeptide Y receptors, have been mapped by interspecific backcross analysis. Previous studies have localized the human genes encoding these receptors to chromosome 4q31-q32. We have now assigned Npy1r and Npy2r to conserved linkage groups on mouse Chr 8 and Chr 3, respectively, which correspond to the distal region of human chromosome 4q. Using yeast artificial chromosomes, we have estimated the distance between the human genes to be approximately 6 cM. Although ancient tandem duplication events may account for some closely spaced G-protein-coupled receptor genes, the large genetic distance between the human type 1 and type 2 neuropeptide Y receptor genes raises questions about whether this mechanism accounts for their proximity.

References

Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·T L Yang-FengU Francke
Sep 29, 1995·The Journal of Biological Chemistry·P M RoseR Seethala
May 1, 1994·Trends in Pharmacological Sciences·L Grundemar, R Håkanson
May 1, 1994·Mammalian Genome : Official Journal of the International Mammalian Genome Society·L B RoweE H Birkenmeier
May 1, 1996·Genomics·R W DeBry, M F Seldin
Jul 12, 1996·The Journal of Biological Chemistry·D H WeinbergD J MacNeil

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