Neuropeptide Y stabilizes body temperature and prevents hypotension in endotoxaemic rats

The Journal of Physiology
Melanie FeliesHeike Nave

Abstract

The on-going high mortality from sepsis motivates continuous research for novel therapeutic strategies. Neuropeptide Y (NPY), a sympathetic neurotransmitter, has been shown to increase survival in experimental septic shock in rats. This protective effect might be due to immunological, cardiovascular or thermoregulatory effects. The aim of this study was to examine the in vivo effect of peripherally administered NPY on body temperature, blood pressure and heart rate in endotoxaemic animals. In order to obtain clinically relevant data, various physiological parameters were monitored in parallel via radio-telemetry in chronically intravenously cannulated, freely behaving rats. Rats received a sublethal bolus of lipopolysaccharide (LPS, 100 microg kg(-1) I.V.) and the three parameters were continuously recorded for 72 h. Endotoxaemic rats showed a long-lasting hypotension, an initial hypothermia (-0.5 degrees C), followed by a prolonged febrile phase (+1.6 degrees C 6 h after endotoxin challenge) associated with a decrease of the circadian rhythm amplitude of temperature. Pretreatment with NPY (160 pmol kg(-1) I.V. over 75 min) prevented hypotension and significantly stabilized body temperature immediately following the application...Continue Reading

References

Jan 1, 1990·Annals of the New York Academy of Sciences·J M LundbergJ Pernow
May 1, 1994·Trends in Pharmacological Sciences·L Grundemar, R Håkanson
Feb 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·E T RietschelF Di Padova
Nov 15, 2002·Journal of Biomedical Science·Ru P LeeHsing I Chen
Jan 1, 2003·Journal of Neuroimmunology·Sammy BedouiStephan von Hörsten

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Citations

Sep 21, 2010·Naunyn-Schmiedeberg's Archives of Pharmacology·Hui-Chun KuMing-Jai Su
Jan 12, 2013·Current Protein & Peptide Science·Daria AugustyniakFionnuala T Lundy
Nov 15, 2011·Resuscitation·Jakobea Benz-WoernerMauro Oddo
Nov 15, 2011·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Jan StadlerHeike Nave
Jul 30, 2008·Nutrition·Karl G HofbauerJean-Christophe Peter
Jul 25, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Huixian YeZhonghong Gao
Apr 29, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Leah MacDonaldStephen Kent
Apr 22, 2020·PloS One·Gwendolyn VliegenIngrid De Meester
Feb 3, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Eyup S Akarsu, Soner Mamuk

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