Neuropeptide-Y stimulates growth hormone and gonadotropin-II secretion in the goldfish pituitary: involvement of both presynaptic and pituitary cell actions

Endocrinology
C PengJ E Rivier

Abstract

We have previously reported that neuropeptide-Y (NPY) stimulates GH and gonadotropin-II (GtH-II) release from perifused pituitary fragments in the goldfish. Since the teleost pituitary is directly innervated by neurosecretory terminals from the brain, we further investigated the possible sites of action of NPY. Both synthetic human NPY and NPY-(18-36), an agonist selective for the NPY Y2-receptor, stimulated GH and GtH-II release from the pituitary fragments; the magnitude of the response to NPY (18-36) was smaller than that to the whole molecule of NPY. NPY also stimulated the release of GH and GtH-II from perifused dispersed pituitary cells. In contrast, NPY-(18-36) had no effect on either GH or GtH-II release from dispersed pituitary cells. These data suggest that Y2 action is not direct at the level of pituitary cells, but may be indirect through actions on nerve terminals in the pituitary. The hypothesis that the action of NPY on GH and GtH-II release is mediated in part by GnRH was then tested. Both NPY and NPY-(18-36) stimulated the GnRH release from preoptic-anterior hypothalamic slices and pituitary fragments with similar potency. Furthermore, a GnRH antagonist significantly reduced the effects of NPY on both GH and Gt...Continue Reading

Citations

Apr 1, 2005·Fish Physiology and Biochemistry·Nishikant SubhedarSubhash Saha
Jan 29, 2008·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Hiroyuki KaiyaSuraj Unniappan
May 22, 2009·Annals of the New York Academy of Sciences·Manuel D GaheteJusto P Castaño
Jan 13, 2006·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Anderson O L WongWendy K W Ko
Jun 27, 2014·General and Comparative Endocrinology·Soham SahaPraful S Singru
Apr 1, 1997·General and Comparative Endocrinology·J J ZouR E Peter
Apr 12, 2014·Frontiers in Endocrinology·Md ShahjahanIshwar S Parhar
Sep 24, 1999·The Journal of Comparative Neurology·A CastroR Anadón
Oct 21, 2000·Endocrine Reviews·J Schwartz
Mar 10, 2001·The Anatomical Record·F J Rodríguez-GómezJ A Muñoz-Cueto
Aug 17, 2012·Biology of Reproduction·Ronald GonzalezSuraj Unniappan
Feb 16, 2017·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Dong-Neng JiangGuang-Li Li
Dec 22, 1999·The American Journal of Physiology·J M Cerdá-ReverterS Zanuy
Mar 27, 2004·Experimental Biology and Medicine·Lloyd L AndersonColin G Scanes
Sep 18, 2020·Molecular and Cellular Endocrinology·Luis Fabián Canosa, Juan Ignacio Bertucci
Jun 6, 2019·Theriogenology·Azadeh Hatef, Suraj Unniappan
Jun 15, 2021·Frontiers in Aging Neuroscience·Huan CuiYuguang Huang

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