Neuropeptide Y, stressful life events and personality trait conscientiousness: Preliminary associations from a Swedish longitudinal study

Psychiatry Research
Philippe A MelasYvonne Forsell

Abstract

The heritability of the Five-Factor Model (FFM) of human personality is high, but few genes have been identified to underlie FFM traits. Neuropeptide Y (NPY) is a pleiotropic gene implicated in stress resilience that contains two well-studied functional SNPs: (1) rs16147, which lies in the NPY promoter and affects expression levels, and (2) rs16139, which lies in the coding sequence of NPY's precursor peptide, pre-pro NPY, and affects precursor processing. In the present study we examined whether these two polymorphisms are associated with FFM traits, using a Swedish cohort (rs16147, N = 2113; and rs16139, N = 1971), and found a significant association with rs16139. Specifically, the minor G-allele of the SNP, which encodes proline instead of leucine and leads to higher processing of pre-pro NPY into mature NPY, was associated with higher levels of conscientiousness. Next, we looked at exposure to life adversities, both in childhood and adulthood, and found that stressful life events were significantly associated with reduced levels of conscientiousness. These data provide insights into the neurobiology of human personality. However, given the difficulty in replicating genetic and environmental associations with behaviorally co...Continue Reading

References

Sep 1, 1975·Journal of Human Stress·T Theorell, C R Rahe
Aug 1, 1974·Archives of General Psychiatry·R H RaheR J Arthur
Nov 1, 1994·Psychological Bulletin·A Feingold
Aug 25, 2001·Journal of Personality and Social Psychology·Paul T CostaRobert R McCrae
Dec 18, 2002·Journal of Neurobiology·Thomas J Bouchard, Matt McGue
May 22, 2003·Journal of Personality and Social Psychology·Sanjay SrivastavaJeff Potter
Nov 25, 2003·Journal of Neural Transmission·B Ding
Nov 17, 2006·Scandinavian Journal of Psychology·Jacek Hochwälder
Jan 9, 2008·Journal of Personality and Social Psychology·David P SchmittJüri Allik
Oct 30, 2008·Molecular Psychiatry·A TerraccianoP T Costa
Mar 7, 2009·Journal of Affective Disorders·Louise K SjöholmCatharina Lavebratt
Aug 18, 2009·Cellular and Molecular Life Sciences : CMLS·Joongkyu ParkKwang Chul Chung
Feb 6, 2010·Journal of Medical Ethics·Philippe A MelasCatharina Lavebratt
May 4, 2010·Psychological Science·Colin G DeYoungJeremy R Gray
Dec 22, 2010·Molecular Psychiatry·M H M de MoorD I Boomsma
Feb 9, 2011·Archives of General Psychiatry·Brian J MickeyJon-Kar Zubieta
Aug 26, 2011·Frontiers in Psychology·Yanna J WeisbergJacob B Hirsh
Oct 7, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hagit CohenAleksander A Mathé
Jan 25, 2012·Cellular and Molecular Neurobiology·Dalay Hirsch, Zofia Zukowska
Jul 18, 2012·Molecular Psychiatry·R Sah, T D Geracioti
Jan 2, 2013·Developmental Psychology·Brent W RobertsPatrick L Hill
Feb 6, 2013·Frontiers in Endocrinology·Xavier Pedragosa-BadiaAnnette G Beck-Sickinger
May 10, 2013·Frontiers in Genetics·Harold T BaeThomas T Perls
Aug 2, 2013·Journal of Human Genetics·Han-Na KimHyung-Lae Kim
Dec 30, 2014·The International Journal of Neuropsychopharmacology·Laili SoleimaniJ John Mann
Sep 24, 2016·Neuropeptides·Yoshikage Muroi, Toshiaki Ishii

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Citations

Apr 10, 2021·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Xin QiFeng Zhang

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