Neuropeptide Y system in the retina: From localization to function

Progress in Retinal and Eye Research
Ana Santos-CarvalhoCláudia Cavadas

Abstract

The retina is a highly complex structure where several types of cells communicate through countless different molecules to codify visual information. Each type of cells plays unique roles in the retina, presenting a singular expression of neurotransmitters. Some neurotransmitter systems in the retina are well understood, while others need to be better explored to unravel the intricate signaling system involved. Neuropeptide Y (NPY), a 36 amino acid peptide, is one of the most common peptide neurotransmitter in the CNS and a highly conserved peptide among species. We review the localization of NPY and NPY receptors (mainly NPY Y1, Y2, Y4 and Y5) in retinal cells. Common features of the expression of NPY and NPY receptors in mammalian and non-mammalian species indicate universal roles of this system in the retina. In the present review, we highlight the putative roles of NPY receptor activation in the retina, discussing, in particular, their involvement in retinal development, neurotransmitter release modulation, neuroprotection, microglia and Muller cells function, retinal pigmented epithelium changes, retinal endothelial physiology and proliferation of retinal progenitor cells. Further studies are needed to confirm that targeti...Continue Reading

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Citations

Apr 18, 2018·The Journal of Comparative Neurology·Anders Tolstrup ChristiansenJens Hannibal
Aug 4, 2019·Journal of Clinical Medicine·Davide CerviaGiovanni Casini
Mar 27, 2019·Scientific Reports·Alexandre A Nikonov, Karen P Maruska
May 24, 2019·International Journal of Molecular Sciences·Maurizio CammalleriAlbertino Bigiani

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